Evidence map›Paper›PMID 39887636›Full record

ArticleAutism research : official journal of the International Society for Autism Research2025

m

Sierra S Nishizaki, Nicholas K Haghani, Gabriana N La, Natasha Ann F Mariano, José M Uribe-Salazar, Gulhan Kaya, Melissa Regester, Derek Sayre Andrews, Christine Wu Nordahl, David G Amaral and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. mNature reviews. Neuroscience · 2026
    Review
  2. CNPI: Rapid Analyses of Human Copy Number Data.Journal of molecular biology · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sierra S NishizakiGenome Center, University of California, Davis, CA, USA.ORCID 0000-0002-4288-4567
Nicholas K HaghaniGenome Center, University of California, Davis, CA, USA.ORCID 0000-0002-0489-9776
Gabriana N LaGenome Center, University of California, Davis, CA, USA.ORCID 0000-0002-9007-3355
Natasha Ann F MarianoGenome Center, University of California, Davis, CA, USA.ORCID 0000-0002-6665-4512
José M Uribe-SalazarGenome Center, University of California, Davis, CA, USA.ORCID 0000-0003-4875-818X
Gulhan KayaGenome Center, University of California, Davis, CA, USA.ORCID 0000-0003-3142-7886
Melissa RegesterDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, CA, USA.
Derek Sayre AndrewsAutism Research Training Program, University of California, Davis, CA, USA.ORCID 0000-0002-1129-3211
Christine Wu NordahlAutism Research Training Program, University of California, Davis, CA, USA.ORCID 0000-0003-1021-4515
David G AmaralAutism Research Training Program, University of California, Davis, CA, USA.ORCID 0000-0003-1525-8744
Megan Y DennisGenome Center, University of California, Davis, CA, USA.ORCID 0000-0002-8502-5420

Funding

Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JUDY A. VAN DE WATER · 2020 to 2026
$9.7M
Interdisciplinary Training for Autism Researchers(RMI)T32MH073124 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI Stephen Charles Noctor, Christine Wu Nordahl · 2004 to 2026
$6.8M
Postbaccalaureate Research Education Program at UC DavisR25GM116690 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOANNA Chungyen CHIU · 2017 to 2026
$3.7M
The function of duplicated genes in human brain evolution and diseaseDP2MH119424 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DENNIS, MEGAN Y · 2018 to 2018
$2.4M
The UC Davis enhanced Molecular, Cellular, and Developmental Biology Training ProgramT32GM153586 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Frederic Louis Chedin, ELVA D DIAZ · 2024 to 2026
$2.3M
Parallel assessment of neurodevelopment genes implicated in autism using zebrafishR21NS128811 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DENNIS, MEGAN Y · 2023 to 2024
$630k
National Institute of Child Health and Human Development P50HD103526NICHD NIH HHS P50 HD103526NIGMS NIH HHS R25 GM116690NIGMS NIH HHS R25GM116690NIGMS NIH HHS T32 GM153586NIGMS NIH HHS T32GM153586NIMH NIH HHS DP2 MH119424NIMH NIH HHS DP2MH119424NIMH NIH HHS T32 MH073124NIMH NIH HHS T32MH073124NINDS NIH HHS R21 NS128811NINDS NIH HHS R21NS128811NINDS NIH HHS R21NS128811-01A1W1
6 · The paper itself

Abstract

Among autistic individuals, a subphenotype of disproportionate megalencephaly (ASD-DM) seen at three years of age is associated with co-occurring intellectual disability and poorer prognoses later in life. However, many of the genes contributing to ASD-DM have yet to be delineated. In this study, we identified additional ASD-DM candidate genes with the aim to better define the genetic etiology of this subphenotype of autism. We expanded the previously studied sample size of ASD-DM individuals ten fold by including probands from the Autism Phenome Project and Simons Simplex Collection, totaling 766 autistic individuals meeting the criteria for megalencephaly or macrocephaly and revealing 154 candidate ASD-DM genes harboring de novo protein-impacting variants. Our findings include 14 high confidence autism genes and seven genes previously associated with DM. Five impacted genes have previously been associated with both autism and DM, including CHD8 and PTEN. By performing functional network analysis, we expanded to additional candidate genes, including one previously implicated in ASD-DM (PIK3CA) as well as 184 additional genes connected with ASD or DM alone. Using zebrafish, we modeled a de novo tandem duplication impacting YTHDF2, encoding an N6-methyladenosine (m

Indexed as

AdenosineAutism Spectrum DisorderAutistic DisorderMegalencephalyRNA-Binding ProteinsAnimalsChild, PreschoolFemaleGenetic Predisposition to DiseaseHumansMaleRNA, MessengerZebrafishAdenosineN-methyladenosineRNA-Binding ProteinsRNA, Messengerautismdisproportionate megalencephalygeneticsm6A‐RNA modificationYTHDF2zebrafish

Identifiers

PMID39887636
PMCPMC12123175

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.