Evidence map›Paper›PMID 39887615›Full record

Trial reportMaternal & child nutrition2025

Piloting Multiple Micronutrient Supplementation Within the Routine Antenatal Care System in Ethiopia: Insights From Stakeholders.

Anene Tesfa Berhanu, Atkure Defar, Girum Taye, Alemneh Kabeta Daba, Senait Alemayehu, Bedasa Tessema, Kalkidan Zenebe, Charles Opondo, Getachew Tollera, Mesay Hailu and 4 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Maternal & child nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05708183 (Healthy Mums, Healthy Babies in Ethiopia), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05708183 recruitingnot on this map

Healthy Mums, Healthy Babies in Ethiopia: a Cluster-randomized Trial to Evaluate the Programme Effectiveness of a Multiple Micronutrient Supplement Delivered to Pregnant Women Through Routine Antenatal Care to Improve Newborn Birthweight

TypeobservationalSponsorLondon School of Hygiene and Tropical MedicineRan2023 to 2025Enrolled25,620ConditionsBirth WeightArmsMultiple micronutrient supplementation (MMS), Iron folate supplementation (IFA)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anene Tesfa BerhanuHealth Systems and Reproductive Health Department, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.ORCID 0000-0003-3513-1097
Atkure DefarDepartment of Disease Control, London School of Hygiene & Tropical Medicine, London, UK.
Girum TayeHealth Systems and Reproductive Health Department, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Alemneh Kabeta DabaFood Science and Nutrition Research Department, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.ORCID 0000-0002-5043-5526
Senait AlemayehuHealth Systems and Reproductive Health Department, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Bedasa TessemaFood Science and Nutrition Research Department, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Kalkidan ZenebeFood Science and Nutrition Research Department, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Charles OpondoDepartment of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK.
Getachew TolleraDeputy Director Office, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Mesay HailuDirector General, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Joanna SchellenbergDepartment of Disease Control, London School of Hygiene & Tropical Medicine, London, UK.
Lars Ake PerssonDepartment of Disease Control, London School of Hygiene & Tropical Medicine, London, UK.
Tanya MarchantDepartment of Disease Control, London School of Hygiene & Tropical Medicine, London, UK.
Masresha TessemaFood Science and Nutrition Research Department, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In low and middle-income countries, addressing maternal and child nutrition needs is crucial. Prenatal multiple micronutrient supplementation (MMS) holds promise in reducing low birthweight and preterm births. Ethiopia is considering a transition from the provision of iron-folate supplementation to the provision of MMS in antenatal care, guided by WHO guidelines. This paper explores stakeholders' early perceptions and experiences in piloting that transition in five Ethiopian regions, informing decision making about future policy and scale-up. We used a qualitative study involving interviews and document reviews to assess the MMS pilot, analyzing themes with Nvivo 12 software. Key informant interviews revealed challenges such as supply chain issues and funding constraints, along with proposed improvement strategies such as closer coordination within existing structures. The importance of engaging with communities to create demand was emphasized, as was the need for capacity-building efforts utilizing existing staff in the health system with a clear plan for ongoing refresher training. Finally, enhancing the monitoring and evaluation framework, including a dedicated regional team for supportive supervision, was vital for accountability. In conclusion, prioritizing supply chain strengthening, community engagement through demand creation, coordination, and continuous capacity building for healthcare workers were thought to be crucial for the MMS program's success.

trial registrationClinicalTrials.gov Identifier: NCT05708183 Registered 01 February 2023-Retrospectively registered, https://classic.clinicaltrials.gov/ct2/show/NCT05708183.

Indexed as

Dietary SupplementsMicronutrientsPrenatal CareAdultEthiopiaFemaleHumansPilot ProjectsPregnancyQualitative ResearchStakeholder ParticipationMicronutrientsantenatal carecapacity‐buildingchild nutritionmaternal nutritionmicronutrient deficienciesprogram implementationstakeholder perceptions

Identifiers

PMID39887615
PMCPMC11956033

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.