Evidence map›Paper›PMID 39887131›Full record

ArticleDermatology reports2025

Growth hormone deficiency and secondary adrenal insufficiency in petrified ear syndrome: a case report and literature review.

Sebastiano Recalcati, Alberto Vassallo, Marta Villanova, Roberto Lanzi, Marco Losa, Maria Grazia Patricelli, Paola Carrera, Fabrizio Fantini

Abstract read
In one paragraph

Article in Dermatology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sebastiano RecalcatiDermatology Unit, Alessandro Manzoni Hospital, ASST Lecco.ORCID 0000-0001-5709-6689
Alberto VassalloInstitute of Endocrine and Metabolic Sciences, Vita-Salute San Raffaele University, Milan.
Marta VillanovaInstitute of Endocrine and Metabolic Sciences, Vita-Salute San Raffaele University, Milan.
Roberto LanziInternal Medicine Department, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan.
Marco LosaNeurosurgery Department, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan.
Maria Grazia PatricelliUnit of Genomics for Human Disease Diagnosis, IRCCS San Raffaele Hospital, Milan.
Paola CarreraUnit of Genomics for Human Disease Diagnosis, IRCCS San Raffaele Hospital, Milan.
Fabrizio FantiniDermatology Unit, Alessandro Manzoni Hospital, ASST Lecco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Petrified ear is a rare clinical entity characterized by the progressive hardening of normal, flexible auricular cartilage, leading to partial or complete auricular stiffness. In many cases, it provides a valuable clinical clue that allows the clinician to detect endocrinopathies (particularly Addison's disease) in a patient who has not received a diagnosis. We present the first documented case of petrified ears, which resulted in the diagnosis of both secondary hypoadrenalism and growth hormone deficiency (GHD). Additionally, we review the relevant literature. Petrified ear syndrome is probably an underreported clinical manifestation of other systemic disorders. It may, at times, serve as a valuable and simple clinical clue to suspect underlying endocrinopathies even in the absence of typical features.

Identifiers

PMID39887131
PMCPMC12439463

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.