Evidence map›Paper›PMID 39886969›Full record

ArticleMolecular medicine reports2025

Preconditioning with acteoside ameliorates myocardial ischemia‑reperfusion injury by targeting HSP90AA1 and the PI3K/Akt signaling pathway.

Jing Li, Yuxin Guo, Yang Yang, Qing Xue, Hong Cao, Guangyuan Yang, Linlin Jia, Haibo Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Antioxidant and Anti-Inflammatory Properties ofAntioxidants (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Article
  4. Current issues in molecular biology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jing Li *Department of Physiology, Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang 154000, P.R. China.
Yuxin Guo *Department of Physiology, Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang 154000, P.R. China.
Yang YangDepartment of Physiology, Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang 154000, P.R. China.
Qing XueDepartment of Cardiology, The First Affiliated Hospital to Jiamusi University, Jiamusi, Heilongjiang 154000, P.R. China.
Hong CaoDepartment of Cardiology, The First Affiliated Hospital to Jiamusi University, Jiamusi, Heilongjiang 154000, P.R. China.
Guangyuan YangDepartment of Cardiology, The First Affiliated Hospital to Jiamusi University, Jiamusi, Heilongjiang 154000, P.R. China.
Linlin JiaDepartment of Physiology, Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang 154000, P.R. China.
Haibo YuDepartment of Cardiology, The First Affiliated Hospital to Jiamusi University, Jiamusi, Heilongjiang 154000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to investigate the cardioprotective effects of acteoside (AC) on myocardial ischemia‑reperfusion injury (MIRI). To meet this aim, a network pharmacological analysis was conducted to search for key genes and signaling pathways associated with AC and MIRI. The infarct size of the rat heart was evaluated using 2,3,5‑triphenyltetrazolium chloride staining, and the serum levels of creatine kinase MB isoenzyme, cardiac troponin I, malondialdehyde and superoxide dismutase were subsequently detected in an

Indexed as

GlucosidesHSP90 Heat-Shock ProteinsMyocardial Reperfusion InjuryPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionAnimalsApoptosisCardiotonic AgentsDisease Models, AnimalMaleMyocardiumOxidative StressPolyphenolsRatsRats, Sprague-DawleyacteosideCardiotonic AgentsGlucosidesHSP90 Heat-Shock ProteinsPhosphatidylinositol 3-KinasesPolyphenolsProto-Oncogene Proteins c-aktReactive Oxygen SpeciesacteosideGSK‑3βHSP90AA1myocardial ischemia‑reperfusion injuryPI3K/Akt signaling pathway

Identifiers

PMID39886969
PMCPMC11795246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.