Evidence map›Paper›PMID 39886890›Full record

ReviewCurrent opinion in neurology2025

Can brain network analyses guide epilepsy surgery?

Ghassan S Makhoul, Derek J Doss, Dario J Englot

Abstract readReview
In one paragraph

Review in Current opinion in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ghassan S MakhoulDepartment of Biomedical Engineering at Vanderbilt University.
Derek J DossDepartment of Biomedical Engineering at Vanderbilt University.
Dario J EnglotDepartment of Biomedical Engineering at Vanderbilt University.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Medical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8M
Relating Vigilance to Connectivity and Neurocognition in Temporal Lobe EpilepsyR01NS112252 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ENGLOT, DARIO J · 2019 to 2023
$3.0M
Development of multimodal network analyses to improve epilepsy surgery outcomesR01NS134625 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dario J Englot · 2024 to 2026
$2.0M
NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284NINDS NIH HHS R01 NS112252NINDS NIH HHS R01 NS134625
6 · The paper itself

Abstract

purpose of reviewEpilepsy surgery is a potentially curative intervention for medically refractory epilepsy. In the last several decades, epilepsy has been studied as a network disorder. How has this disease model influenced surgical interventions? RECENT

findingsSurgical outcomes for resection are increasingly being tied to network features, such as node hubness score. These findings imply that measuring network features may augment epileptologist seizure onset zone designation for surgical planning. Network models are also leveraged for neuromodulation, specifically in studies with thalamic targets. Recent findings suggest that the thalamus may function as a reasonable target for neuromodulation because of its role in the seizure propagation networks. SUMMARY: In this review, we discuss the degree these models of epilepsy are influencing surgery today and barriers for the widespread adoption of network models when planning epilepsy surgery.

Indexed as

BrainDrug Resistant EpilepsyEpilepsyNerve NetNeurosurgical ProceduresHumans

Identifiers

PMID39886890
PMCPMC11882367

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.