Evidence map›Paper›PMID 39886793›Full record

ArticleCurrent topics in medicinal chemistry2025

Galegine, a Bioprivileged Alkaloid from

Noor Ul Ain Nawaz, Muhammad Saeed, Shaheen Faizi, Irfan Ali, Muhammad Shafiq, Muhammad Shahid, Fazle Rabbi, Fahim Ullah Khan, Rabeea Sharif, Zaheer Ul-Haq and 5 more

Abstract read
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In one paragraph

Article in Current topics in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Noor Ul Ain NawazDepartment of Pharmacy, City University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Muhammad SaeedDepartment of Pharmacy, Qurtuba University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Shaheen FaiziH. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Sindh, Pakistan.
Irfan AliH. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Sindh, Pakistan.
Muhammad ShafiqH. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Sindh, Pakistan.
Muhammad ShahidDepartment of Pharmacy, CECOS University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Fazle RabbiDepartment of Pharmacy, Abasyn University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Fahim Ullah KhanDepartment of Pharmacy, City University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Rabeea SharifPeshawar Institute of Cardiology, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Zaheer Ul-HaqH. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Sindh, Pakistan.
Khalid Mohammed KhanH. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Sindh, Pakistan.
Hassan A HemegDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Al-Medinah, Al-Monawara, Saudi Arabia.
Waleed Al AbdulmonemDepartment of Pathology, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Abdullah S M AljohaniDepartment of Medical Biosciences, College of Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia.
Abdur RaufDepartment of Chemistry, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan.ORCID 0000-0003-2429-5491

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn continuation of our chemical and biological work on

objectiveGiven the biological importance of guanidine and in search of safe antipyretic agents from natural resources, an

methods

resultsBoth the extract and galegine showed a progressive dose-dependent reduction in body temperatures of the hyperthermic test animals. Moreover,

conclusionThese biological and computational approaches supported

Indexed as

AlkaloidsAntipyreticsFeverAnimalsCyclooxygenase 1Cyclooxygenase 2Dose-Response Relationship, DrugMaleMiceMolecular Docking SimulationMolecular StructurePlant ExtractsStructure-Activity RelationshipAlkaloidsAntipyreticsCyclooxygenase 1Cyclooxygenase 2Plant ExtractsGalegineguanidine derivativehemiterpenenatural productspyrexiaTithonia tubaeformis.

Identifiers

PMID39886793

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.