Evidence map›Paper›PMID 39886742›Full record

ArticleDevelopment and psychopathology2025

Associations of polygenic scores and developmental trajectories of externalizing behaviors.

A Brooke Sasia, Katherine G Jonas, Monika A Waszczuk, James J Li

Abstract read
In one paragraph

Article in Development and psychopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A Brooke SasiaDepartment of Psychology, University of Wisconsin-Madison, Madison, WI, USA.ORCID https://orcid.org/0000-0002-1311-6606
Katherine G JonasDepartment of Psychiatry and Behavioral Health, Stony Brook University School of Medicine, USA.ORCID https://orcid.org/0000-0002-1910-223X
Monika A WaszczukDepartment of Psychology, Rosalind Franklin University of Medicine and Science, USA.ORCID https://orcid.org/0000-0003-1775-1970
James J LiDepartment of Psychology, University of Wisconsin-Madison, Madison, WI, USA.ORCID https://orcid.org/0000-0001-8031-7216

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7M
Wave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1M
Project 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MICHAEL F MILES · 2014 to 2026
$19.6M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5M
The development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6M
Using the Genetic Architecture of Substance Use Disorders to Advance Gene Identification and Understanding of Pathways of RiskR01DA050721 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DANIELLE M DICK · 2020 to 2026
$3.9M
Trajectories and Determinants of Cognitive Decline in Psychotic Disorders Over 35 YearsR01MH135119 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI Katherine G Jonas, Roman I Kotov · 2024 to 2026
$2.3M
The impact of early life adversity on brain network development in youthR01MH128371 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Rasmus Matthias Birn · 2022 to 2026
$1.9M
Integrating developmental and genomic approaches to identify early trajectories of eating and internalizing disorder symptomsR01MH134039 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Nadia Micali, Jin Peng Szatkiewicz · 2024 to 2026
$1.6M
Twin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3M
Optimized Phenotypes for Genetic Association StudiesR21MH123908 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI JONAS, KATHERINE G · 2020 to 2020
$448k
NIAAA NIH HHS K02 AA018755NIAAA NIH HHS P50 AA022537NIAAA NIH HHS R01 AA015416NIAAA NIH HHS U10 AA008401NICHD NIH HHS P01 HD031921NICHD NIH HHS P50 HD105353NIDA NIH HHS R01 DA050721NIMH NIH HHS R01 MH128371NIMH NIH HHS R01 MH134039NIMH NIH HHS R01 MH135119NIMH NIH HHS R21 MH123908
6 · The paper itself

Abstract

Polygenic scores (PGSs) have garnered increasing attention in the clinical sciences due to their robust prediction signals for psychopathology, including externalizing (EXT) behaviors. However, studies leveraging PGSs have rarely accounted for the phenotypic and developmental heterogeneity in EXT outcomes. We used the National Longitudinal Study of Adolescent to Adult Health (analytic

Indexed as

antisocial behaviorsdevelopmentexternalizingpolygenic scoressubstance use

Identifiers

PMID39886742
PMCPMC12310988

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.