ArticleCureus2024
Evaluation of the Effect of Topically Applied Melatonin and Vitamin C in the Non-surgical Treatment of Chronic Periodontitis: A Triple-Blind Randomized Clinical Trial.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Melatonin-Hydrogel Delivery Systems for Effective Treatments of Periodontitis: Translational Perspectives from Material Designs to Clinical Applications.Gels (Basel, Switzerland) · 2026Review
- Effect of Melatonin Gel as an Adjunct to Non-Surgical Periodontal Therapy: A Systematic Review of Randomized Controlled Trials.Journal of clinical medicine · 2026Review
- Sleep and circadian disruption reshape immune homeostasis in oral tissues: mechanistic roles of melatonin and cortisol in periodontal disease and xerostomia.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aimed to evaluate the impact of using melatonin and vitamin C as adjuncts to the non-surgical treatment of chronic periodontitis. MATERIALS AND
methodsThis triple-blind randomized clinical trial involved 100 participants with chronic periodontitis. Subjects were randomly assigned to three groups: (1) non-surgical periodontal therapy (NSPT) alone (n = 33); (2) NSPT with melatonin (n = 33); and (3) NSPT with melatonin and vitamin C (n = 34). Clinical parameters, including gingival index (GI), probing depth (PD), and clinical attachment loss (CAL), were assessed at baseline and at one week, one month, and three months post treatment. Statistical significance was set at p ≤ 0.05.
resultsCompared to baseline, all groups showed significant improvements in periodontal parameters (p ≤ 0.001). At three months, the group receiving both melatonin and vitamin C demonstrated the greatest reduction in PD (mean reduction: 1.96 mm, p ≤ 0.001) and CAL (mean reduction: 1.87 mm, p ≤ 0.001). This group also achieved the most significant improvement in GI (mean reduction: 1.74, p ≤ 0.001).
conclusionsThe combined adjunctive therapy of melatonin and vitamin C demonstrated superior improvements in periodontal indices compared to NSPT alone, supporting its potential as an effective adjunctive treatment for chronic periodontitis.
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Registered trials
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