ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Sex differences for regional pathology in people with a high likelihood of Lewy body dementia phenotype based on underlying pathology.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex differences inFrontiers in dementia · 2025Pooled it
- Sex differences for clinical presentations and co-pathologies in four-repeat tauopathies.Biology of sex differences · 2026Article
- Sex-Specific Associations of α-Synuclein Pathology With Tau Accumulation.JAMA network open · 2026Article
- Where do PDD and DLB SYNdromes fit in neuronal alpha-SYNuclein biological frameworks?Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Sex differences for symptoms prior to dementia onset in people with Lewy body pathology compared to pure Alzheimer's disease pathology.Journal of Alzheimer's disease : JAD · 2026Article
- Sex and gender differences in Lewy body dementia: a narrative review.Equity neuroscience · 2025Article
- Article
- Sex differences for regional pathology in people with a high likelihood of Lewy body dementia phenotype based on underlying pathology.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
6 authors.
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Abstract
Introduction: Clinicopathological correlations differ by sex in Lewy body dementia (LBD). However, previous studies have focused on pathological staging systems that place less emphasis on regional pathologies. Methods: We included 357 people (131 female, 226 male) with a high likelihood of LBD based on pathology from the Brain Bank for Neurodegenerative (Jacksonville, FL). Sex differences for regional Lewy body, senile plaque, and neurofibrillary tangle counts and their associations with clinical LBD diagnosis were assessed. Results: Females were less likely to have a clinical LBD diagnosis; they had more Lewy bodies, neurofibrillary tangles, and senile plaques in various regions than males (all Discussion: Sex differences for clinicopathological correlations in LBD also occur at the regional pathology level. Females have a higher frequency of clinical misdiagnosis than males. Highlights: Females have a higher risk of clinical underdiagnosis for Lewy body dementia (LBD) than males.Regional pathology counts differ by sex for people with a high likelihood of LBD.Regional pathology association with clinical LBD diagnosis differs by sex.Regional Lewy body counts have a stronger association with LBD phenotype for males.
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