ArticleJACC. Advances2025
Medium-Term Effects of Increased Water Intake and Head-Up Sleep on Cardiovascular Health.
Article in JACC. Advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- We Do Not Know Whether Head-Up Sleep Enhances Erythropoiesis.Acta physiologica (Oxford, England) · 2026Article
- Does Calcium Supplementation Negate Erythropoiesis With Endurance Training?Acta physiologica (Oxford, England) · 2025Article
- Sleep Posture and Hydration: Simple Lifestyle Interventions With Therapeutic Cardiovascular Health Potential?JACC. Advances · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Whether medium-term increased water intake alone, or in combination with co-adjuvant nonexercise interventions aimed to expand blood volume (BV), improve the human cardiovascular phenotype and cardiorespiratory fitness remains unexplored. Objectives: The purpose of this study was to determine the medium-term impact of increased (+40%) fluid (water) intake (IFI) or IFI plus head-up sleep (IFI + HUS) on BV and the cardiovascular phenotype in healthy individuals. Methods: Healthy adults (n = 35, age 42 ± 18 years, 51% female) matched by sex, age, body composition, physical activity, and cardiorespiratory fitness were randomly allocated to IFI or IFI + HUS for 3 months. Body composition and BV were determined via DXA and indicator-dilution methods. Cardiac filling, output, and peak O Results: Intravascular volumes, comprising plasma and red blood cell volumes, were not modified by IFI or IFI + HUS. Cardiac volumes at rest, specifically left ventricular (LV) end-diastolic volume and stroke volume (SV), and systolic emptying rate were increased after IFI and IFI + HUS ( Conclusions: Medium-term increased water intake largely expands the resting volume and output of the LV while reducing arterial elastance and cardiac afterload, without altering intravascular volumes, cardiac or aerobic capacities. With the addition of HUS, relaxation properties of the resting LV are further improved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.