Evidence map›Paper›PMID 39886221›Full record

ArticleChemical & biomedical imaging2025

Line-Shifting Triarylmethyl Radicals for Imaging of Enzyme Activity Using Overhauser-Enhanced Magnetic Resonance Imaging: Application to Alkaline Phosphatase.

Murugesan Velayutham, Martin Poncelet, Ayano Enomoto, Justin L Huffman, Virat G Pandya, Kazuhiro Ichikawa, Valery V Khramtsov, Benoit Driesschaert

Abstract read
In one paragraph

Article in Chemical & biomedical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Murugesan VelayuthamDepartment of Biochemistry and Molecular Medicine, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID https://orcid.org/0009-0001-9751-538X
Martin PonceletIn Vivo Multifunctional Magnetic Resonance Center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia 26506, United States.
Ayano EnomotoFaculty of Pharmaceutical Sciences, Nagasaki International University, Nagasaki 859-3298, Japan.
Justin L HuffmanIn Vivo Multifunctional Magnetic Resonance Center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia 26506, United States.
Virat G PandyaIn Vivo Multifunctional Magnetic Resonance Center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia 26506, United States.
Kazuhiro IchikawaFaculty of Pharmaceutical Sciences, Nagasaki International University, Nagasaki 859-3298, Japan.
Valery V KhramtsovDepartment of Biochemistry and Molecular Medicine, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID https://orcid.org/0000-0001-6187-5546
Benoit DriesschaertIn Vivo Multifunctional Magnetic Resonance Center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID https://orcid.org/0000-0002-1402-413X

Funding

Profiling chemical tumor microenvironment: Application for diagnostics & therapyR01CA192064 · NCI · WEST VIRGINIA UNIVERSITY · PI EUBANK, TIMOTHY D, KHRAMTSOV, VALERY V · 2015 to 2024
$3.4M
Biocompatible triarylmethyl radical-based dendrimers as nonmetallic contrast agents for MRIR01EB032321 · NIBIB · WEST VIRGINIA UNIVERSITY · PI DRIESSCHAERT, BENOIT · 2022 to 2025
$1.5M
Imaging enzyme activity by Overhauser-enhanced MRIR21EB028553 · NIBIB · WEST VIRGINIA UNIVERSITY · PI DRIESSCHAERT, BENOIT · 2020 to 2022
$599k
Electron Spin Resonance Microfluidics as a new tool in chemical single cell population analysisR21GM143595 · NIGMS · WEST VIRGINIA UNIVERSITY · PI BLANK, AHARON, DRIESSCHAERT, BENOIT · 2022 to 2023
$387k
NCI NIH HHS R01 CA192064NIBIB NIH HHS R01 EB032321NIBIB NIH HHS R21 EB028553NIGMS NIH HHS R21 GM143595
6 · The paper itself

Abstract

Enzyme catalytic activities are critical biomarkers of tissue states under physiological and pathophysiological conditions. However, the direct measurement and imaging of enzyme activity

Identifiers

PMID39886221
PMCPMC11775853

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.