ArticleFrontiers in pharmacology2024
Walnut oil prevents hyperlipidemia induced by high-fat diet and regulates intestinal flora and liver metabolism.
Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations between lipid metabolism and Henoch-Schönlein purpura nephritis in children: a systematic review and meta-analysis.Italian journal of pediatrics · 2026Pooled it
- Investigating the phytotherapeutic efficacy ofFrontiers in pharmacology · 2026Article
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Authors and funding
6 authors.
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Abstract
Objective: This study aims to investigate the preventive effect of walnut oil as medicinal food on abnormal lipid metabolism and its influence on liver metabolites and intestinal flora. Methods: The rat model of abnormal lipid metabolism was established by feeding high-fat diet and administering a high-fat emulsion via gavage. The rats were randomly assigned to one of the five groups: the normal group (ND), the model group (HFD), and three walnut oil intervention groups differing in dosage [low-dose (OL, 2.5 g/kg. BW/day), medium-dose (OM, 5 g/kg. BW/day) and high-dose (OH, 10 g/kg. BW/day)]. Modeling and administration were performed simultaneously for 10 weeks. After the last administration, the serum and organs of the animals were collected under anesthesia, and the organ index was analyzed. Serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) were measured. A histopathological examination of the liver was performed, and the intestinal flora was detected by Illumina technology. Results: Compared to the ND group, the HFD group exhibited a significant increase in body weight and Lee's index. Compared to the HFD group, each walnut oil intervention group showed a relatively reduced degree of liver swelling and a significant decrease in fat vacuoles within the cytoplasm. Levels of TC, TG, LDL-C, activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly decreased ( Conclusion: Walnut oil can significantly prevent hyperlipidemia caused by high-fat diet. The mechanism is mainly through significantly reducing the content of MDA and the activities of ALT and AST, significantly increasing the activity of GSH-PX, and improving intestinal flora and liver metabolism.
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