ArticleBMC pharmacology & toxicology2025
Drug-related macular edema: a real-world FDA Adverse Event Reporting System database study.
Article in BMC pharmacology & toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
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Who cites it
9 citing papers in PubMed.
- Real‑world analysis of Macular Oedema associated with Paclitaxel Formulations using the Japanese Adverse Drug Event Report database.PloS one · 2026Article
- From toxicity to signal: positioning symptom clusters as pharmacodynamic indicators in ICI therapy.Frontiers in pharmacology · 2026Review
- Piperacillin/Tazobactam-Induced Bilateral Optic Disc Edema With Serous Retinal Fluid in a Young Female With Pelvic Abscess and Sepsis.Case reports in infectious diseases · 2026Article
- Hepatobiliary Adverse Events Linked to Immune Checkpoint Inhibitors: A Real-World Pharmacovigilance Analysis Using FAERS Data.Thoracic cancer · 2025Article
- Real-world pharmacovigilance analysis of drug-related cataracts using the FDA adverse event reporting system database.Frontiers in pharmacology · 2025Article
- Drug-induced polycystic ovary syndrome: a real-world pharmacovigilance study based on the FAERS database.Frontiers in endocrinology · 2025Article
- Chloroquine and hydroxychloroquine-related ocular adverse events in SLE treatment: a real-world disproportionality analysis based on FDA adverse event reporting system (FAERS).Frontiers in pharmacology · 2025Article
- Update of safety profile of bile acid sequestrants: A real-world pharmacovigilance study of the FDA adverse event reporting system.PloS one · 2025Article
- Nab-Paclitaxel-Induced Cystoid Macular Edema with Minimal Fluorescein Leakage: A Case Report of Two Patients from a Tertiary Referral Center.Case reports in ophthalmologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeThis study aims to assess the risks associated with drug-induced macular edema and to examine the epidemiological characteristics of this condition.
methodsThis study analyzed data from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database from January 2004 to June 2024 to conduct a disproportionality analysis identifying drugs with positive signals of drug-induced ME. Additionally, the onset time of ME associated with these drugs was examined.
resultsIn the FAERS database, a total of 490 drugs were reported to pose a risk of drug-induced ME. Disproportional analysis and screening further identified 8 drugs that significantly increased this risk. Among these, one is ophthalmic drugs, including Latanoprost (ROR = 5.51), and ten are non-ophthalmic drugs, including Cefuroxime (ROR = 75.93), Fingolimod (ROR = 30.69), and Siponimod (ROR = 20.51).
conclusionsThis study utilizes the FAERS database to investigate potential associations between drug use and the occurrence of ME, rapidly identify drugs that may induce the condition, and propose research strategies. These findings hold significant value for guiding clinical medication practices.
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