Evidence map›Paper›PMID 39885602›Full record

ArticleExperimental hematology & oncology2025

A non-conditioned bone marrow transplantation mouse model to study clonal hematopoiesis and myeloid malignancies.

Sofia Bentivegna, Marwa Almosailleakh, Lin-Pierre Zhao, Mikkel Bruhn Schuster, Sébastien Benquet, Alexander Balhuizen, Helga Fibiger Munch-Petersen, Lene Dissing Sjö, Mads Hald Andersen, Nicolas Dulphy and 2 more

Abstract readLetter
In one paragraph

Article in Experimental hematology & oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sofia BentivegnaDepartment of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Marwa AlmosailleakhDepartment of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Lin-Pierre ZhaoHôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France.
Mikkel Bruhn SchusterBiotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark.
Sébastien BenquetBiotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark.
Alexander BalhuizenBiotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark.
Helga Fibiger Munch-PetersenDepartment of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Lene Dissing SjöDepartment of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Mads Hald AndersenNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Nicolas DulphyINSERM UMR 1160, Institut de Recherche Saint-Louis, Université Paris Cité, Paris, France.
Bo PorseBiotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark.
Kirsten GrønbækDepartment of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. kirsten.groenbaek@regionh.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) is a condition where blood or bone marrow cells carry mutations associated with hematological malignancies. Individuals with CHIP have an increased risk of developing hematological malignancies, atherosclerotic cardiovascular disease, and all-cause mortality. Bone marrow transplantation (BMT) of cells carrying CHIP mutations into irradiated mice are useful procedures to investigate the dynamics of clonal expansion and potential therapeutic strategies, but myeloablative conditioning can induce confounding effects. We established a non-conditioned BMT model using C57BL/6J-Kit

Identifiers

PMID39885602
PMCPMC11781034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.