ArticleJournal of ovarian research2025
Whole exome sequencing-based homologous recombination deficiency test for epithelial ovarian cancer.
Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
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5 authors.
Funding
Abstract
backgroundThe homologous recombination deficiency (HRD) test is an important tool for identifying patients with epithelial ovarian cancer (EOC) benefit from the treatment with poly(adenosine diphosphate-ribose) polymerase inhibitor (PARPi). Using whole exome sequencing (WES)-based platform can provide information of gene mutations and HRD score; however, the clinical value of WES-based HRD test was less validated in EOC.
methodsWe enrolled 40 patients with EOC in the training cohort and 23 in the validation cohort. The WES-based HRD score was calculated using the scarHRD software. We first evaluated the concordance of the HRD status defined by the Myriad MyChoice CDx and then assessed the value of HRD on clinical prognosis in patients with EOC.
resultsThe HRD score defined by the WES-based test was positively correlated with that of the Myriad MyChoice
conclusionThe WES-based test is a potential option for determining the HRD status in EOC patients, and desires for further validation in large-scale cohorts.
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