ArticleScientific reports2025
Non-targeted metabolomics reveals fatty acid and associated pathways driving resistance to whitefly and tomato leafminer in wild tomato accessions.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Integrated Transcriptomic and Metabolomic Analyses Reveal Dose-Dependent Effects of Bamboo Compost on Tomato Growth and Resistance toInternational journal of molecular sciences · 2026Article
- γ-Valerolactone Reprograms Tomato Metabolism to Enhance Seedling Growth.Metabolites · 2026Article
- Basic Research on Whitefly Molecular Biology: A Foundation for Innovative Pest Management Strategies.Current issues in molecular biology · 2026Review
- Metabolic and Biochemical Responses of Heirloom and Hybrid Tomato (Solanum lycopersicum) Under Flooding, Specialist, and Generalist Insect Herbivory, and their Stress Combination.Journal of chemical ecology · 2026Article
- Plant resistance: scientific basis and latest research progress.Frontiers in plant science · 2026Review
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7 authors.
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Abstract
Wild tomato species exhibit natural insect resistance, yet the specific secondary metabolites and underlying mechanisms governing the resistance remain unclear. Moreover, defense expression dynamically adapts to insect herbivory, causing significant metabolic changes and species-specific secondary metabolite accumulation. The present study aims to identify the resistance-related metabolites in wild tomato accessions that influence the defense mechanism against whitefly (Bemisia tabaci Asia II 7) and leafminer (Phthorimaea absoluta). In this study, LC-HRMS-based non-targeted metabolomics of resistant wild (Solanum cheesmaniae and Solanum galapagense) and susceptible cultivated (Solanum lycopersicum) accessions following 6- and 12-h post-infestation (hpi) by B. tabaci Asia II 7 and P. absoluta revealed distinct sets of resistance-related constitutive (RRC) and induced (RRI) metabolites. The key resistance-related metabolites were those involved in the fatty acid and associated biosynthesis pathways (e.g., triacontane, di-heptanoic acid, dodecanoic acid, undecanoic acid, N-hexadecanoic acid, pentacosane, monogalactosyldiacylglycerols, sphinganine, and 12-hydroxyjasmonic acid), which are recognized for their direct or indirect role in mediating plant defense against insects. Additionally, the differential accumulation of metabolites was evident through partial least squares-discriminant analysis (PLS-DA), highlighting differences in metabolite profiles between resistant and susceptible accessions at 6 and 12 hpi of B. tabaci and P. absoluta. Volcano plot analysis revealed a higher number of significantly upregulated metabolites in wild accessions following herbivory. Moreover, wild tomato accessions responded uniquely to B. tabaci and P. absoluta, highlighting species-specific metabolic responses of tomato accessions to the two feeding guilds. This study uncovered biochemical mechanisms governing resistance in wild tomato accessions, elucidated the influence of dual herbivory on the plant metabolome, and offered well-characterized parent materials and candidate metabolites for breeding insect-resistant varieties.
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