ArticleNature communications2025
Liquid crystal monomers induce placental development and progesterone release dysregulation through transplacental transportation.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Decadal accumulation of display materials in pristine soils of the Three Poles.Environmental science and ecotechnology · 2026Article
- PFAS-defined liquid crystal monomers: An overlooked class of organofluorine contaminants.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Thermal-enhanced self-heating microneedle patch for sustained progesterone delivery and improved pregnancy maintenance.Materials today. Bio · 2026Article
- SR-B1-Mediated Transplacental Transfer of Hydrophobic Toxicants Disrupts Fetal Development During Barriergenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Liquid Crystal Monomers as Emerging Contaminants: Contaminated Distribution, Environmental Behavior, Detection Technologies, and Future Challenges.Environment & health (Washington, D.C.) · 2025Review
- Liquid Crystal Monomers and Their Mixtures Alter Nuclear Receptor Signaling and Promote Adipogenesis In Vitro.Endocrinology · 2025Article
- [Occurrence characterization of fluorinated liquid crystal monomers in indoor dust and human health exposure risks].Se pu = Chinese journal of chromatography · 2025Article
- Inverted day-night feeding during pregnancy affects the brain health of both maternal and fetal brains through increasing inflammation levels associated with dysbiosis of the gut microbiome in rats.Journal of neuroinflammation · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryonic and fetal development can be affected during gestation by exposure to xenobiotics that cross the placenta. Liquid crystal monomers (LCMs) are emerging contaminants commonly found in indoor environments; however, whether they can cross the placenta and affect placental development remains unexplored. Here, we develop an evaluation system that integrates human biomonitoring, uterine perfusion in pregnant rats, and placental cells. We find fourteen out of the fifty-six LCMs that are detected in maternal and cord serum samples from ninety-three healthy pregnant women, at median levels of 13.9 and 18.1 ng/mL, respectively. Subsequent explorations of in utero exposure in rats indicate that aromatic amino acid transporter 1 (SLC16A10) mediates transplacental transportation of the LCMs. Placental cells exposed to LCMs exhibit delayed placental development and reduced progesterone release. These findings show that SLC16A10-mediated transplacental transportation of LCMs inhibits placental development and progesterone release, highlighting the importance of gestational exposure to emerging contaminants.
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Registered trials
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