ArticleNature communications2025
Stress landscape of folding brain serves as a map for axonal pathfinding.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Nature communications · 2026Article
- Brain structure and function in Homo naledi.Brain structure & function · 2026Review
- Mechanisms of inflammatory response in secondary brain injury: a review of computational approaches, challenges, and future directions.Biomechanics and modeling in mechanobiology · 2026Review
- Personalized Estimates of Brain Cortical Structural Similarity in Major Depressive Disorder: Evidence from a Multi-Site Neuroimaging Dataset.Diagnostics (Basel, Switzerland) · 2026Article
- How do infant brains fold? Sulcal deepening is linked to development of sulcal span, thickness, curvature, and microstructure.Communications biology · 2026Article
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Research square · 2026Article
- A subject-specific reversible folding model reveals geometry-driven white-matter organization.bioRxiv : the preprint server for biology · 2025Article
- Astrocytes in white matter respond to tensile cues during cortical folding: a numerical study.bioRxiv : the preprint server for biology · 2025Article
- Mechanical characterization of brain tissue: experimental techniques, human testing considerations, and perspectives.Acta biomaterialia · 2025Review
- Mechanics of the Spatiotemporal Evolution of Sulcal Pits in the Folding Brain.Human brain mapping · 2025Article
- Mechanical stress connects cortical folding to fiber organization in the developing brain.Trends in neurosciences · 2025Review
- Article
- Stress landscape of folding brain serves as a map for axonal pathfinding.Nature communications · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Understanding the mechanics linking cortical folding and brain connectivity is crucial for both healthy and abnormal brain development. Despite the importance of this relationship, existing models fail to explain how growing axon bundles navigate the stress field within a folding brain or how this bidirectional and dynamic interaction shapes the resulting surface morphologies and connectivity patterns. Here, we propose the concept of "axon reorientation" and formulate a mechanical model to uncover the dynamic multiscale mechanics of the linkages between cortical folding and connectivity development. Simulations incorporating axon bundle reorientation and stress-induced growth reveal potential mechanical mechanisms that lead to higher axon bundle density in gyri (ridges) compared to sulci (valleys). In particular, the connectivity patterning resulting from cortical folding exhibits a strong dependence on the growth rate and mechanical properties of the navigating axon bundles. Model predictions are supported by in vivo diffusion tensor imaging of the human brain.
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Registered trials
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