Evidence map›Paper›PMID 39885102›Full record

ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2025

Comparison of postoperative oxygenation in children receiving sugammadex versus neostigmine for reversal of neuromuscular blockade: a retrospective cohort study.

Stephania Paredes, Sascha Ott, Julian Rössler, Busra T Cekmecelioglu, Carlos Trombetta, Yufei Li, Alparslan Turan, Kurt Ruetzler, Surendrasingh Chhabada

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stephania Paredes *Division of Multi-Specialty Anesthesiology, Department of Anesthesiology & Pain Management, Cleveland Clinic, Cleveland, OH, USA.
Sascha Ott *Outcomes Research Consortium, Houston, TX, USA.
Julian RösslerOutcomes Research Consortium, Houston, TX, USA.
Busra T CekmeceliogluDivision of Multi-Specialty Anesthesiology, Department of Anesthesiology & Pain Management, Cleveland Clinic, Cleveland, OH, USA.
Carlos TrombettaDivision of Multi-Specialty Anesthesiology, Department of Anesthesiology & Pain Management, Cleveland Clinic, Cleveland, OH, USA.
Yufei LiOutcomes Research Consortium, Houston, TX, USA.
Alparslan TuranDivision of Multi-Specialty Anesthesiology, Department of Anesthesiology & Pain Management, Cleveland Clinic, Cleveland, OH, USA.
Kurt RuetzlerDivision of Multi-Specialty Anesthesiology, Department of Anesthesiology & Pain Management, Cleveland Clinic, Cleveland, OH, USA. kr@or.org.ORCID 0000-0003-0467-1736
Surendrasingh ChhabadaOutcomes Research Consortium, Houston, TX, USA.

Funding

Research Support, Non-US Gov’t
6 · The paper itself

Abstract

purposeResidual neuromuscular blockade can impair postoperative respiratory mechanics, promoting hypoxemia and pulmonary complications. Sugammadex, with its unique mechanism of action, may offer a more effective reversal of neuromuscular blockade and respiratory function than neostigmine. We sought to test the primary hypothesis that children undergoing noncardiac surgery exhibit better initial recovery oxygenation when administered sugammadex than those administered neostigmine. Furthermore, we aimed to investigate if children administered sugammadex experience fewer in-hospital pulmonary complications.

methodsIn a retrospective cohort study, we analyzed data from children aged 2-17 yr who underwent noncardiac surgery with general anesthesia and received neostigmine or sugammadex between January 2017 and April 2023 at the Cleveland Clinic Main Campus. Our primary outcome was postoperative oxygenation defined by the mean SpO

resultsAmong 3,523 cases, 430 (12.5%) involved sugammadex and 3,081 (87.5%) involved neostigmine. The median [interquartile range] of the mean SpO

conclusionIn this retrospective cohort study, postoperative oxygenation was similar in children after reversal of neuromuscular blockade with sugammadex versus neostigmine.

Indexed as

NeostigmineNeuromuscular BlockadeOxygenSugammadexAdolescentAnesthesia, GeneralAnesthesia Recovery PeriodChildChild, PreschoolCholinesterase InhibitorsCohort StudiesFemaleHumansMalePostoperative ComplicationsRetrospective StudiesCholinesterase InhibitorsNeostigmineOxygenSugammadexneuromuscular blockadepostoperative oxygenationpulmonary complicationssugammadex

Identifiers

PMID39885102

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.