ArticleCognitive, affective & behavioral neuroscience2025
Anhedonia relates to reduced striatal reward anticipation in depression but not in schizophrenia or bipolar disorder: A transdiagnostic study.
Article in Cognitive, affective & behavioral neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Temporal Dynamics of Reward Dysfunction in Psychiatric Disorders: Memory-Derived Value, Incentive Salience, Hedonic Impact, and Value Updating.Biological psychiatry global open science · 2026Review
- Neuromodulatory Gating of Synaptic Plasticity: Mechanisms, Motivation, and Clinical Dysfunction Across Scales.Synapse (New York, N.Y.) · 2026Review
- Understanding Anticipatory Anhedonia in Schizophrenia and Depression: Linking Reward Representation Maintenance from a Transdiagnostic Perspective.Schizophrenia bulletin · 2026Article
- Blunted anticipation, but not consummation, of food rewards in depression.Cell reports. Medicine · 2026Article
- From Neural Circuits to Behavior: Examining the Central Role of Anhedonia in Major Depression.Advances in experimental medicine and biology · 2026Review
- Pathways to anhedonia in unmedicated major depressive disorder: the roles of insecure attachment and emotion dysregulation.Frontiers in psychiatry · 2026Article
- Anhedonia in Depressive Disorder and Schizophrenia: An Overview of Causes, Diagnosis, and Treatment.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Trait reward sensitivity and behavioral motivation are associated with connectivity between the default mode network and the striatum during reward anticipation.bioRxiv : the preprint server for biology · 2025Article
- Neural Correlates of Reward Processing: Impact of Individual Differences in Preference for Prosocial Interactions.Brain and behavior · 2025Article
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Authors and funding
11 authors.
Funding
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Abstract
Anhedonia, i.e., the loss of pleasure or lack of reactivity to reward, is a core symptom of major psychiatric conditions. Altered reward processing in the striatum has been observed across mood and psychotic disorders, but whether anhedonia transdiagnostically contributes to these deficits remains unclear. We investigated associations between self-reported anhedonia and neural activation during reward anticipation and consumption across patients with schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MD), and healthy controls (HC). Using the Monetary Incentive Delay paradigm, we acquired functional magnetic resonance imaging data sets in 227 participants (18-65 years), including patients with SZ (n = 44), BD (n = 47), MD (n = 56), and HC (n = 80). To capture anhedonia, three items of the Symptom Checklist-90-R were entered into exploratory factor analysis, which resulted in a single anhedonia factor. Associations between anhedonia and neural activation were assessed within a striatal region-of-interest and exploratorily across the whole brain (p
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