Evidence map›Paper›PMID 39884997›Full record

ArticleIntensive care medicine experimental2025

Dexmedetomidine alleviates acute kidney injury in a rat model of veno-arterial extracorporeal membrane oxygenation.

Min Yu, Shilin Wei, Xueyang Shen, Junjie Ying, Dezhi Mu, Xiangyang Wu, Yongnan Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Min Yu *Department of Anesthesiology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China.
Shilin Wei *Department of Thoracic Surgery, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China.
Xueyang ShenDepartment of Neurology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China.
Junjie YingDepartment of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Dezhi MuDepartment of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Xiangyang WuDepartment of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou University, No. 80, Cuiyingmen, Chengguan District, Lanzhou, 730030, China.
Yongnan LiDepartment of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou University, No. 80, Cuiyingmen, Chengguan District, Lanzhou, 730030, China. lyngyq2006@foxmail.com.

Funding

National Key R&D Program of China 2021YFC2701700National Key R&D Program of China 2021YFC2701704the Natural Sciences Foundation of Gansu 23JRRA0972the Natural Sciences Foundation of Gansu 23JRRA1502the Natural Sciences Foundation of Gansu 23JRRA1619the Science and Technology Planning Project of Chengguan District 2022RCCX0023the Talent Introduction Plan of the Lanzhou University Second Hospital YJRCKYQDJ-2021-02
6 · The paper itself

Abstract

backgroundAlthough extracorporeal membrane oxygenation (ECMO) is an effective technique for life support, the incidence of acute kidney injury (AKI) during ECMO support remains high. Dexmedetomidine (DEX), which has been widely used for sedation during ECMO, possesses several properties that help reduce the occurrence of AKI. This study aimed to investigate the protective effect of DEX on kidney function during ECMO.

methodsA total of 18 male Sprague-Dawley (SD) rats were randomly divided into three groups: Sham, ECMO, and ECMO + DEX groups. ECMO was established through the right jugular vein for venous drainage and right femoral artery for arterial infusion and lasts for four hours. Hematoxylin and eosin staining was used to evaluate the kidney Paller score for the rats in each group. Enzyme-linked immunosorbent assay was used to measure the levels of kidney injury biomarkers and cytokines in the serum. Reagent kits were used to measure the blood urea nitrogen (BUN) and creatinine (Cr) levels, which helped determine kidney function. Immunohistochemical staining was used to evaluate neutrophil infiltration in the kidney.

resultsThe pathological Paller score was substantially lower in the ECMO + DEX group. The levels of Kidney Injury Molecule-1 (KIM-1) and N-acetyl-β-D-glucosaminidase (NAG) were also significantly reduced. The kidney functionality, as indicated by BUN and Cr, was significantly improved compared with the ECMO group. The levels of cytokines IL-6, IL-1β, and TNF-α, were also significantly decreased in the ECMO + DEX group.

conclusionThis study demonstrated that dexmedetomidine could reduce inflammatory response and alleviate AKI during ECMO support.

Indexed as

Acute kidney injuryDexmedetomidineVeno‐arterial extracorporeal membrane oxygenation

Identifiers

PMID39884997
PMCPMC11782784

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.