ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025
Clinical and prognostic insights into Chlamydia trachomatis in pediatric acute respiratory infections: evidence from targeted next-generation sequencing of 5,021 cases.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A tNGS-based comparative study on clinical features and co-detection profiles of hospitalized children with influenza A and B viruses.Frontiers in medicine · 2026Article
- Laboratory detection methods for Chlamydia trachomatis infection in children: a review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
- Machine learning-based identification of inflammatory biomarkers for predicting pulmonary consolidation in children with Chlamydia pneumoniae infection.Frontiers in pediatrics · 2026Article
- Targeted next-generation sequencing for pediatric lower respiratory tract infections: a retrospective study.Frontiers in cellular and infection microbiology · 2025Article
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Abstract
backgroundChlamydia trachomatis (CT) is a major cause of respiratory tract infections in children. The primary objective of this research was to evaluate the infection status and clinical manifestations associated with C. trachomatis in these pediatric patients.
methodsFrom April 2021 to November 2023, a total of 5,021 hospitalized children with acute respiratory tract infections were collected at the Guangxi Maternal and Child Health Hospital. tNGS was used to detect pathogens in their respiratory samples.
resultsAmong the 5,021 hospitalized pediatric patients with acute respiratory tract infections, targeted next-generation sequencing (tNGS) detected C. trachomatis in 138 cases, with a detection rate of 2.75%. Among the 138 cases positive for C. trachomatis, 10 were identified as single C. trachomatis infection, while 128 cases involved co-infections with other pathogens. A total of 36 additional pathogens were detected in children with mixed Chlamydia trachomatis infections, with Pneumocystis jirovecii being the most frequently detected. In children with C. trachomatis infection, pulmonary consolidation and hypoxemia were the most commonly observed respiratory complications, whereas anemia and liver function impairment were the primary complications affecting other organ systems. The median duration of hospitalization for the 138 children was 8 days. Among the 138 children with C. trachomatis infection, 108 cases (78.26%) required respiratory support, and 11 cases (7.97%) required ICU admission.
conclusionThe detection rate of C. trachomatis among hospitalized pediatric patients with respiratory tract infections was 2.75%. This study delineates the clinical manifestations and infection patterns of C. trachomatis in Guangxi, China.
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