Case report: Vulvar metastasis after lung metastasis in cervical squamous cell carcinoma, a case report and literature review.

Ze-Lan Liao, Ka-Na Wang, Jia-Wen Zhang

Abstract readCase Reports

In one paragraph

Article in International journal of surgery case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Metastatic Carcinomas at the Episiotomy Site: A Systematic Literature Review.Cancers · 2025
Review

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ze-Lan LiaoDepartment of Obstetrics and Gynecology, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu, China; Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.

Ka-Na WangDepartment of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.

Jia-Wen ZhangDepartment of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. Electronic address: zjw66662023@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and importanceCervical cancer is highly correlated with high-risk human papillomavirus (HPV) infection, accounting for approximately 70 % of cases. However, false-negative HPV test results can occur, complicating early detection. CASE PRESENTATION: We introduce a rare case of cervical cancer with lung metastasis followed by vulvar metastasis. Notably, the HPV test was negative at diagnosis but became positive upon detection of vulvar metastasis. CLINICAL DISCUSSION: We discuss the pathways of vulvar metastasis in cervical cancer and potential causes of false-negative HPV tests. A search for cases of vulvar metastasis of cervical cancer in Medline and Embase between 2004 and 2024 was performed and a literature review was conducted.

conclusionThe occurrence of vulvar metastasis indicates the terminal manifestation of the tumor and the survival period is short. Active radiotherapy, chemotherapy, immunotherapy and other multiple treatments may increase the overall survival time of patients.

Indexed as

Cervical squamous cell carcinoma, vulvar metastasisHPV, false negative, therapy

Identifiers

PMID39884173

DOI10.1016/j.ijscr.2025.110816

PMCPMC11815689

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