Evidence map›Paper›PMID 39883929›Full record

ArticleJMIR research protocols2025

User-Oriented Requirements for Artificial Intelligence-Based Clinical Decision Support Systems in Sepsis: Protocol for a Multimethod Research Project.

Pascal Raszke, Godwin Denk Giebel, Carina Abels, Jürgen Wasem, Michael Adamzik, Hartmuth Nowak, Lars Palmowski, Philipp Heinz, Silke Mreyen, Nina Timmesfeld and 3 more

Abstract read
In one paragraph

Article in JMIR research protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pascal RaszkeInstitute for Health Care Management and Research, University of Duisburg-Essen, Essen, Germany.ORCID 0009-0008-6538-0733
Godwin Denk GiebelInstitute for Health Care Management and Research, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0002-4182-1927
Carina AbelsInstitute for Health Care Management and Research, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0003-2138-2944
Jürgen WasemInstitute for Health Care Management and Research, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0001-9653-168X
Michael AdamzikDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Knappschaftskrankenhaus, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0002-7188-4873
Hartmuth NowakDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Knappschaftskrankenhaus, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0002-6509-1463
Lars PalmowskiDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Knappschaftskrankenhaus, Ruhr University Bochum, Bochum, Germany.ORCID 0009-0008-9553-6575
Philipp HeinzKnappschaft Kliniken GmbH, Recklinghausen, Germany.ORCID 0009-0007-5331-5785
Silke MreyenKnappschaft Kliniken GmbH, Recklinghausen, Germany.ORCID 0009-0002-1013-8428
Nina TimmesfeldDepartment of Medical Informatics, Biometry and Epidemiology, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0002-5175-4326
Marianne TokicDepartment of Medical Informatics, Biometry and Epidemiology, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0001-9789-575X
Frank Martin BrunkhorstGerman Sepsis Society, Jena, Germany.ORCID 0000-0002-8132-8651
Nikola BlaseInstitute for Health Care Management and Research, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0003-3774-5009

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundArtificial intelligence (AI)-based clinical decision support systems (CDSS) have been developed for several diseases. However, despite the potential to improve the quality of care and thereby positively impact patient-relevant outcomes, the majority of AI-based CDSS have not been adopted in standard care. Possible reasons for this include barriers in the implementation and a nonuser-oriented development approach, resulting in reduced user acceptance.

objectiveThis research project has 2 objectives. First, problems and corresponding solutions that hinder or support the development and implementation of AI-based CDSS are identified. Second, the research project aims to increase user acceptance by creating a user-oriented requirement profile, using the example of sepsis.

methodsThe research project is based on a multimethod approach combining (1) a scoping review, (2) focus groups with physicians and professional caregivers, and (3) semistructured interviews with relevant stakeholders. The research modules mentioned provide the basis for the development of a (4) survey, including a discrete choice experiment (DCE) with physicians. A minimum of 6667 physicians with expertise in the clinical picture of sepsis are contacted for this purpose. The survey is followed by the development of a requirement profile for AI-based CDSS and the derivation of policy recommendations for action, which are evaluated in a (5) expert roundtable discussion.

resultsThe multimethod research project started in November 2022. It provides an overview of the barriers and corresponding solutions related to the development and implementation of AI-based CDSS. Using sepsis as an example, a user-oriented requirement profile for AI-based CDSS is developed. The scoping review has been concluded and the qualitative modules have been subjected to analysis. The start of the survey, including the DCE, was at the end of July 2024.

conclusionsThe results of the research project represent the first attempt to create a comprehensive user-oriented requirement profile for the development of sepsis-specific AI-based CDSS. In addition, general recommendations are derived, in order to reduce barriers in the development and implementation of AI-based CDSS. The findings of this research project have the potential to facilitate the integration of AI-based CDSS into standard care in the long term. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/62704.

Indexed as

Artificial IntelligenceDecision Support Systems, ClinicalSepsisFocus GroupsHumansResearch DesignSurveys and Questionnairesartificial intelligencebloodstream infectionCDSSclinical decision support systemscomputational intelligencedecision supportmachine learningmedical informaticssepsis

Identifiers

PMID39883929
PMCPMC11826947

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.