Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors.
Yu-Ting Su *Department of Biological Sciences, College of Liberal Arts and Sciences, Wayne State University, Detroit, MI 48202.
Sydney M Quagliato *Department of Biological Sciences, College of Liberal Arts and Sciences, Wayne State University, Detroit, MI 48202.ORCID 0000-0001-8901-8415
Brendyn M St LouisDepartment of Biological Sciences, College of Liberal Arts and Sciences, Wayne State University, Detroit, MI 48202.ORCID 0000-0001-8639-5098
Mohamed H AbdelazizDepartment of Biochemistry, Microbiology, and Immunology, School of Medicine, Wayne State University, Detroit, MI 48201.
Yuan HeDepartment of Biochemistry, Microbiology, and Immunology, School of Medicine, Wayne State University, Detroit, MI 48201.
Devanand BondageDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892.
Stephanie S LehmanDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892.
Pei-Chung LeeDepartment of Biological Sciences, College of Liberal Arts and Sciences, Wayne State University, Detroit, MI 48202.ORCID 0000-0002-8352-7152
Funding
Virulence strategies of the respiratory pathogen Legionella pneumophilaZIAHD008893 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MACHNER, MATTHIAS · 2010 to 2025
$19.6M
Molecular mechanism of NLRP3 inflammasome activationR01AI148544 · NIAID · WAYNE STATE UNIVERSITY · PI HE, YUAN · 2020 to 2025
$1.9M
Regulation of Innate Immunity by the Hippo KinasesR21AI182688 · NIAID · WAYNE STATE UNIVERSITY · PI LEE, PEI-CHUNG · 2024 to 2025
$416k
HHS | National Institutes of Health (NIH) AI148544HHS | National Institutes of Health (NIH) AI182688Intramural NIH HHS ZIA HD008893NIAID NIH HHS R01 AI148544NIAID NIH HHS R21 AI182688Wayne State University (WSU) Startup fundWayne State University (WSU) University Research Grant 2020-2021
6 · The paper itself
Abstract
The mammalian Hippo kinases, MST1 and MST2, regulate organ development and suppress tumor formation by balancing cell proliferation and death. In macrophages, inflammasomes detect molecular patterns from invading pathogens or damaged host cells and trigger programmed cell death. In addition to lytic pyroptosis, the signatures associated with apoptosis are induced by inflammasome activation, but how the inflammasomes coordinate different cell death processes remains unclear. Here, we identify the crucial role of MST1/2 in inflammasome-triggered cell death. Macrophages proteolytically convert full-length MST1/2 into the MST1/2 N-terminal fragments (MST1/2-NT) when the NLRC4 inflammasome detects flagellin from the pathogenic bacterium,
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Activation of the conserved Hippo kinases by inflammasome-triggered proteolytic cleavage controls programmed cell death in macrophages. · full record | OpenQuestion