Evidence map›Paper›PMID 39883652›Full record

ReviewAnalytical chemistry2025

Communicating with Stakeholders to Identify High-Impact Research Directions for Non-Targeted Analysis.

Sara L Nason, James McCord, Yong-Lai Feng, Jon R Sobus, Christine M Fisher, Ruth Marfil-Vega, Allison L Phillips, Gregory Johnson, John Sloop, Stéphane Bayen and 3 more

Abstract readReview
In one paragraph

Review in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sara L NasonConnecticut Agricultural Experiment Station, 123 Huntington Street, New Haven, Connecticut 06511, United States.ORCID 0000-0002-3866-6399
James McCordCenter for Environmental Measurement and Modeling, Office of Research and Development, U.S. Environmental Protection Agency, 109 TW Alexander Drive, Research Triangle Park, North Carolina 27711, United States.ORCID 0000-0002-1780-4916
Yong-Lai FengExposure and Biomonitoring Division, Environmental Health Science and Research Bureau, Health Canada, 251 Sir Frederick Banting Driveway, Ottawa, Ontario K1A 0K9, Canada.ORCID 0000-0002-0353-7239
Jon R SobusCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, 109 TW Alexander Drive, Research Triangle Park, North Carolina 27711, United States.
Christine M FisherHuman Foods Program, U.S. Food and Drug Administration, 5001 Campus Drive, College Park, Maryland 20740, United States.
Ruth Marfil-VegaShimadzu Scientific Instruments, 10330 Old Columbia Road, Columbia, Maryland 21046, United States.
Allison L PhillipsCenter for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 200 SW 35th Street, Corvallis, Oregon 97333, United States.
Gregory JohnsonCity of High Point, NC, Water Quality Laboratory, 121 N. Pendleton Street High Point, North Carolina 27260, United States.
John SloopOak Ridge Institute for Science and Education (ORISE) Participant, 109 TW Alexander Drive, Research Triangle Park, North Carolina 27711, United States.
Stéphane BayenDepartment of Food Science and Agricultural Chemistry, McGill University, 21111 Lakeshore Road, Sainte-Anne-de-Bellevue, Quebec, Canada H9X 3V9.ORCID 0000-0002-9935-6685
Esra MutluCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, 109 TW Alexander Drive, Research Triangle Park, North Carolina 27711, United States.
Angela L BattCenter for Environmental Solutions and Emergency Response, Office of Research and Development, U.S. Environmental Protection Agency, 26 W Martin Luther King Drive, Cincinnati, Ohio 45268, United States.ORCID 0000-0002-7008-249X
Keaton NahanCenter for Devices and Radiological Health, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, United States.ORCID 0000-0001-9326-5697

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

Non-targeted analysis (NTA) using high-resolution mass spectrometry without defined chemical targets has the potential to expand and improve chemical monitoring in many fields. Despite rapid advancements within the research community, NTA methods and data remain underutilized by many potential beneficiaries. To better understand barriers toward widespread adoption, the Best Practices for Non-Targeted Analysis (BP4NTA) working group conducted focus group meetings and follow-up surveys with scientists (n = 61) from various sectors (e.g., drinking water utilities, epidemiologists, n = 9) where NTA is expected to provide future value. Meeting participants included producers and end-users of NTA data with a wide range of familiarity with NTA methods and outputs. Discussions focused on identifying specific barriers that limit adoption and on setting NTA product development priorities. Stated priorities fell into four major categories: 1) education and training materials; 2) QA/QC frameworks and study design guidance; 3) accessible compound databases and libraries; and 4) NTA data linkages with chemical fate and toxicity information. Based on participant feedback, this manuscript proposes research directions, such as standardization of training materials, that BP4NTA and other institutions can pursue to expand NTA use in various application scenarios and decision contexts.

Indexed as

CommunicationMass SpectrometryStakeholder ParticipationFocus GroupsHumans

Identifiers

PMID39883652
PMCPMC11886761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.