ArticlePloS one2025
Feasibility of rabbit auricular VX2 tumor model as an experimental model for intra-arterial embolization.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the feasibility of VX2 tumor in rabbit auricles as an experimental model for intra-arterial embolization. This study was approved by our Institutional Animal Care and Use Committee. VX2 tumors were implanted in both auricles of 12 New Zealand White Rabbits. To investigate the angiographic and pathologic characteristics, angiography, ultrasonography, and thermography were performed 1-2 weeks after inoculation, and image analysis was performed. The animals were sacrificed thereafter, and histologic analysis was conducted by a pathologist. Tumors did not grow in 3/24 auricles of 12 rabbits used in the experiment, and one rabbit died during anesthesia for an ultrasonographic examination. Therefore, images were obtained from a total of 19 auricles. Angiography was successfully performed in 11 rabbits, and hypervascularity and tumor feeding vessels were clearly observed in all tumors. The enhancement effect increased significantly as the volume increased. In histologic evaluation, the average area of necrosis was 27%. In conclusion, a rabbit auricular VX2 tumor model is easy to create, and its features can be conveniently observed on visual inspection. Moreover, it appears hypervascular on angiography, and the tumor feeding vessel is easy to approach. Thus, it is useful for studying intra-arterial embolization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.