Evidence map›Paper›PMID 39883485›Full record

ArticleeLife2025

Glia control experience-dependent plasticity in an olfactory critical period.

Hans C Leier, Alexander J Foden, Darren A Jindal, Abigail J Wilkov, Paola Van der Linden Costello, Pamela J Vanderzalm, Jaeda Coutinho-Budd, Masashi Tabuchi, Heather T Broihier

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Hans C Leier *Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.ORCID https://orcid.org/0000-0002-0363-1444
Alexander J Foden *Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.ORCID https://orcid.org/0000-0001-7244-619X
Darren A JindalDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.
Abigail J WilkovDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.
Paola Van der Linden CostelloDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.
Pamela J VanderzalmDepartment of Biology, John Carroll University, University Heights, United States.
Jaeda Coutinho-BuddDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, United States.
Masashi TabuchiDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.
Heather T BroihierDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.ORCID https://orcid.org/0000-0003-1363-3088

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Medical Scientist Training Program at Case Western Reserve UniversityT32GM152319 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Heather Broihier, Alex Yee-Chen Huang · 2024 to 2026
$5.1M
Mechanisms of Glial Interactions and Function at Neuronal Cell BodiesR01NS121101 · NINDS · UNIVERSITY OF VIRGINIA · PI COUTINHO-BUDD, JAEDA · 2021 to 2025
$2.0M
Retooling innate immunity: An investigation of TLR-mediated glial priming across lifespanR01NS120689 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI BROIHIER, HEATHER · 2021 to 2025
$2.0M
Analysis of innate immune signaling mechanisms mediating neuron-glia interactionsR21NS110397 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI BROIHIER, HEATHER · 2019 to 2019
$429k
NIGMS NIH HHS T32 GM007250NIGMS NIH HHS T32 GM152319NIGMS NIH HHS T32GM152319NINDS NIH HHS R01 NS120689NINDS NIH HHS R01NS120689NINDS NIH HHS R01 NS121101NINDS NIH HHS R21 NS110397NINDS NIH HHS R21NS110397
6 · The paper itself

Abstract

Sensory experience during developmental critical periods has lifelong consequences for circuit function and behavior, but the molecular and cellular mechanisms through which experience causes these changes are not well understood. The

Indexed as

Drosophila melanogasterNeurogliaNeuronal PlasticityOlfactory Receptor NeuronsSmellAnimalsDrosophila ProteinsOdorantsSynapsesDrosophila Proteinscritical periodD. melanogasterDraperMEGF10neuron-glia interactionsneurosciencesynapse pruning

Identifiers

PMID39883485
PMCPMC11781797

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.