ArticleAdvanced biotechnology2023
Optimization of central carbon metabolism by Warburg effect of human cancer cell improves triterpenes biosynthesis in yeast.
Article in Advanced biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Metabolic and transport engineering enable efficient de novo biosynthesis of patchoulol inSynthetic and systems biotechnology · 2026Article
- Unraveling competitive protein interactions: A critical step toward improved production and therapeutics.Journal of advanced research · 2026Review
- Article
- The potential of metabolic engineering for sustainable phytosterol production.Advanced biotechnology · 2026Review
- CCT7 predicts poor prognosis and correlates with immune infiltration in colonic adenocarcinoma.Journal of molecular histology · 2026Article
- Metabolic Engineering of Yeasts for the Production of the Triterpene Squalene: Current Status and Future Prospective.Microorganisms · 2025Review
- The biosynthesis and diversity of taxanes: From pathway elucidation to engineering and synthetic biology.Plant communications · 2025Review
- Overexpression of tRNA mFrontiers in microbiology · 2025Article
- Efficient biosynthesis ofSynthetic and systems biotechnology · 2025Article
- Hyperoxia as a driver of gut dysbiosis.Frontiers in microbiology · 2025Review
- Integrative Transcriptomic and Target Metabolite Analysis as a New Tool for Designing Metabolic Engineering in Yeast.Biomolecules · 2024Article
- Potentiating dual-directional immunometabolic regulation with nanomedicine to enhance anti-tumor immunotherapy following incomplete photothermal ablation.Journal of nanobiotechnology · 2024Article
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Authors and funding
6 authors.
Funding
Abstract
Optimizing central carbon metabolism (CCM) represents an attractive and challenging strategy to improve the biosynthesis of valuable chemicals due to the complex regulation of the CCM in yeast. In this study, we triggered the similar Warburg effect of cancer cells in yeast strains by introducing the human hypoxia-inducible factor-1 (HIF-1) complex, which regulated the expression of numerous enzymes involved in CCM and redirected the metabolic flux from glycolysis to tricarboxylic acid cycle. This redirection promoted the production of squalene to a 2.7-fold increase than the control strain BY4741. Furthermore, the HIF-1 complex boosted the production of represented endogenous triterpenoid ergosterol to 1145.95 mg/L, and exogenous triterpenoid lupeol to 236.35 mg/L in shake flask cultivation, 10.5-fold and 9.2-fold increase than engineered strains without HIF-1 complex integration, respectively. This study provides a novel strategy for optimizing CCM by HIF-1 mediated Warburg effect of cancer cells to improve biosynthesis of triterpenoids in yeast.
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