ArticleUpdates in surgery2025
Correlation between parathyroid adenoma volume and perioperative outcomes in primary hyperparathyroidism: Does the size matter?
Article in Updates in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Do Biochemical Markers Reflect Parathyroid Adenoma Volume in Primary Hyperparathyroidism?International journal of molecular sciences · 2026Article
- Comment to: Correlation between parathyroid adenoma volume and perioperative outcomes in primary hyperparathyroidism: does the size matter?Updates in surgery · 2026Article
- Clinical and Biochemical Correlates of Parathyroid Gland Burden in Patients Undergoing Parathyroidectomy for Secondary Hyperparathyroidism: A Retrospective Observational Study.Journal of clinical medicine · 2026Article
- Age-stratified differences in asymptomatic primary hyperparathyroidism: a single-center cohort study from 2017 to 2024.Gland surgery · 2026Article
- Association of Intraoperative Parathyroid Hormone Decline with Early Postoperative Hypocalcemia: A Single-Center Retrospective Study.Diagnostics (Basel, Switzerland) · 2026Article
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8 authors.
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Abstract
backgroundPrimary hyperparathyroidism (PHPT) due to a parathyroid adenoma stands as one of the most prevalent endocrinological disorders, with focused parathyroidectomy being the established therapeutic strategy.
aimThis study aims to investigate whether the volume of the pathological gland influences perioperative outcomes and postoperative morbidity.
methodsA retrospective analysis was conducted on data from 141 patients who underwent focused parathyroidectomy for PHPT at the University Hospital of Basel between 2007 and 2022.
resultsA total of 141 patients underwent surgery, with a mean age of 57.2 years and prevalence of women (64.5%).The volume of the lesion was divided into three groups (low < 1 ml, middle 1-1.99 ml, large > 2 ml) based on pathological specimen analysis. Preoperative calcium and parathyroid hormone (PTH) values were significantly higher in the large volume group compared to the low volume group (p < 0.05), while phosphate and vitamin D values were significantly lower (p < 0.05). A comparison of adenoma volume in symptomatic patients with asymptomatic patients revealed no statistically significant difference (p = 0.845) and the volume of the gland of any group did not influence the length of the operation (p = 0.173) and the perioperative morbidity (p = 0.108).
conclusionCompared to a volume of less than 1 ml, a parathyroid gland volume greater than 2 ml was associated with higher preoperative PTH and calcium levels and lower phosphate and vitamin D levels. The volume of the parathyroid gland does not seem to impact the clinical manifestations, or the incidence of perioperative complications.
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