ArticlePlant cell reports2025
Transcriptomic insight into zinc dependency of vindoline accumulation in Catharanthus roseus leaves: relevance and potential role of a CrZIP.
Article in Plant cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- GsIRT3: a zinc-iron transporter gene from Glycine soja, enhancing alkali stress tolerance in Arabidopsis thaliana.Journal of plant research · 2026Article
- Article
- Magnesium Plus Hydrogen Fertilization Enhances Mg Uptake, Growth Performance and Monoterpenoid Indole Alkaloid Biosynthesis inPlants (Basel, Switzerland) · 2025Article
- The potential role of short internodes/stylish (SHI/STY) and SHI related sequence (SRS) in potato tuberization.BMC plant biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
key messageFoliar-applied Zn on Catharanthus roseus enhanced production of vindoline, the main impediment precursor for costly anticancer bisindoles. A leaf-abundant CrZIP was characterized for likely role in modulating vindoline metabolism. The leaf-localized Catharanthus roseus alkaloid, vindoline, is the major impediment precursor in the production of scanty and expensive anticancer bisindoles, vinblastine and vincristine. Earlier studies have hinted toward the role of micronutrients in its accumulation. Here, the effect of various micronutrients on the leaf vindoline content was analyzed. Foliar application of zinc (Zn, 100 ppm) was found to be most effective for enhancing the vindoline content. Comparison of leaf samples of Zn-treated and control plants was performed using paired-end transcriptome sequencing and promising candidates among the differentially expressed genes were identified. A zinc-regulated, iron-regulated transporter-like proteins (ZIP) family member, which was found to be upregulated in Zn-treated samples, was taken up for functional characterization. Complementation of the zrt1/zrt2 yeast mutant (ZHY3) by CrZIP suggested that it encodes a functional Zn transporter. VIGS and transient overexpression of CrZIP in C. roseus showed a direct relationship between its expression and vindoline content. GFP fusion-based subcellular localization indicated chloroplast localization of CrZIP. Previously, vindoline biosynthesis has been reported to be dependent on intact chloroplasts. The chloroplast localization of CrZIP and its direct relationship with vindoline content in this study identifies the possible role of CrZIP, in modulating zinc-induced vindoline accumulation in the plant.
Indexed as
Identifiers
39883286What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.