Evidence map›Paper›PMID 39883280›Full record

ArticleJournal of epidemiology and global health2025

Lipid Levels and Lung Cancer Risk: Findings from the Taiwan National Data Systems from 2012 to 2018.

Jung-Yueh Chen, Nai-Hui Chi, Ho-Shen Lee, Chia-Ni Hsiung, Chang-Wei Wu, Kang-Chi Fan, Meng-Rui Lee, Jann-Yuan Wang, Chao-Chi Ho, Jin-Yuan Shih

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In one paragraph

Article in Journal of epidemiology and global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jung-Yueh ChenSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Nai-Hui ChiDepartment of Nursing, National Taiwan University Hospital, Taipei, Taiwan.
Ho-Shen LeeDepartment of Internal Medicine, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan.
Chia-Ni HsiungProgram in Precision Medicine, National Tsing Hua University, Hsinchu, Taiwan.
Chang-Wei WuDepartment of Internal Medicine, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan.
Kang-Chi FanDepartment of Internal Medicine, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan.
Meng-Rui LeeDepartment of Internal Medicine, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan. leemr@ntu.edu.tw.
Jann-Yuan WangDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, No.7, Chung Shan S. Rd., Zhongzheng District, Taipei City, 100225, Taiwan.
Chao-Chi HoDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, No.7, Chung Shan S. Rd., Zhongzheng District, Taipei City, 100225, Taiwan.
Jin-Yuan ShihDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, No.7, Chung Shan S. Rd., Zhongzheng District, Taipei City, 100225, Taiwan.

Funding

National Taiwan University Hospital Hsin-Chu Branch NTUH-HC REC: 109-070-E
6 · The paper itself

Abstract

backgroundLipids are known to be involved in carcinogenesis, but the associations between lipid profiles and different lung cancer histological classifications remain unknown.

methodsIndividuals who participated in national adult health surveillance from 2012 to 2018 were included. For patients who developed lung cancer during follow-up, a 1:2 control group of nonlung cancer participants was selected after matching. Multivariate conditional logistic regression was used to explore the associations between lipid profiles, different lung cancer histological classifications and epidermal growth factor receptor mutation statuses. Subgroup, sensitivity, and dose‒response analyses were also performed.

resultsA total of 4,704,853 participants (30,337 lung cancer participants and 4,674,516 nonlung cancer participants) were included. In both the main and sensitivity analyses, the associations remained constant between lower high-density lipoprotein (HDL) cholesterol levels and a higher risk of lung cancer (main analysis: odds ratio: 1.13 [1.08-1.18]) and squamous cell carcinoma (1.29 [1.16-1.43]). Hypertriglyceridemia was associated with a lower risk of adenocarcinoma (0.90 [0.84-0.96]) and a higher risk of small cell lung cancer (1.31 [1.11-1.55]). Hypercholesterolemia was associated with a lower risk of squamous cell carcinoma (0.84 [0.76-0.94]). In the subgroup analysis, lower HDL cholesterol levels were associated with greater risk across most subgroups. HDL cholesterol levels also demonstrated a dose‒response association with the development of lung cancer.

conclusionsThe distinct associations between specific lipid profiles and lung cancer subtypes suggest that lipid metabolism may play different mechanistic roles in lung cancer development.

Indexed as

LipidsLung NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedRisk FactorsTaiwanLipidsEGFR-mutated lung cancerHigh-density lipoproteinLung cancerTotal cholesterolTriglyceride

Identifiers

PMID39883280
PMCPMC11782738

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.