Evidence map›Paper›PMID 39883245›Full record

ArticleAdvanced biotechnology2024

A human antibody derived from original SARS-CoV-2 infection effectively neutralizes omicron.

Tingting Li, Bingjie Zhou, Haoyu Dong, Dimitri Lavillette, Dianfan Li

Abstract readLetter
In one paragraph

Article in Advanced biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tingting Li *Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200030, China.
Bingjie Zhou *Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200030, China.
Haoyu DongPasteurien College, Soochow University, Jiangsu, China.
Dimitri LavillettePasteurien College, Soochow University, Jiangsu, China. dimitri.lavillette@ip-korea.org.
Dianfan LiCenter for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200030, China. dianfan.li@sibcb.ac.cn.ORCID http://orcid.org/0000-0003-4729-4678

Funding

CAS president's international fellowship initiative 2020VBA0023National Key R&D Program of China 2020YFC0845900National Natural Science Foundation of China 31870153National Natural Science Foundation of China 82151215Science and Technology Commission of Shanghai Municipality 22ZR1468300Shanghai Municipal Science and Technology Major Project 20431900402
6 · The paper itself

Abstract

SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) Variants of Concern (VOCs), such as the Omicron sub-variants, present significant challenges in pandemic control due to their capacity to escape antibodies and breach vaccine protections. Discovering antibodies that can tolerate mutations in VOCs and understanding their underlying mechanisms is crucial for developing therapeutics for COVID-19 patients, particularly those for whom other therapies may be unsuitable. Here, we report the neutralization of the Omicron variant by FD20, a broadly active human monoclonal antibody. In contrast to a clinically approved control antibody, FD20 neutralizes Omicron with comparable IC

Indexed as

Broad neutralizing antibodyCOVID-19Escape mutantsSARS-CoV-2Variant of Concern

Identifiers

PMID39883245
PMCPMC11740836

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.