Evidence map›Paper›PMID 39883227›Full record

ReviewMedical oncology (Northwood, London, England)2025

Natural compounds as modulators of miRNAs: a new frontier in bladder cancer treatment.

Ahmed I Abulsoud, Shaza H Aly, Sherif S Abdel Mageed, Nourhan M Abdelmaksoud, Walaa A El-Dakroury, Osama A Mohammed, Mustafa Ahmed Abdel-Reheim, Mohamed Bakr Zaki, Nehal I Rizk, Manar Mohammed El Tabaa and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ahmed I AbulsoudBiochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, 11231, Egypt.
Shaza H AlyDepartment of Pharmacognosy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Sherif S Abdel MageedPharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Nourhan M AbdelmaksoudBiochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt.
Walaa A El-DakrouryDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Osama A MohammedDepartment of Pharmacology, College of Medicine, University of Bisha, Bisha, 61922, Saudi Arabia.
Mustafa Ahmed Abdel-ReheimDepartment of Pharmacology, College of Pharmacy, Shaqra University, Shaqra, 11961, Saudi Arabia. m.ahmed@su.edu.sa.ORCID https://orcid.org/0000-0002-7728-0923
Mohamed Bakr ZakiDepartment of Biochemistry, Faculty of Pharmacy, University of Sadat City, Menoufia, 32897, Egypt.
Nehal I RizkDepartment of Biochemistry, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Cairo, 11786, Egypt.
Manar Mohammed El TabaaPharmacology & Environmental Toxicology, Environmental Studies & Research Institute (ESRI), University of Sadat City, Sadat City, 32897, Menoufia, Egypt.
Mahmoud RashedPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.
Riham A El-ShiekhPharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Ahmed S DoghishDepartment of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt. ahmed_doghish@azhar.edu.eg.ORCID https://orcid.org/0000-0002-0136-7096

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder cancer (BC) is a major global health issue with a high recurrence rate and limited effective treatments. Over the past few years, it has become evident that miRNAs play a role in the carcinogenesis process, particularly in regulating genes that promote cancer cell proliferation and invasion. This review focuses on the extent to which natural products can act as potential miRNA modulators for the management of bladder cancer. Polyphenols, flavonoids, and other phytochemicals are natural compounds found to have inherent potential to modulate miRNAs and reform the oncogenic properties of bladder cancer cells regulating cell growth and death. In integration with the current cancer treatment regimes, such natural agents may safely substitute for the traditional chemical chemotherapeutic agents of the conventional approaches. To this end, this review presents the existing knowledge of natural compounds as regulators of miRNA, their mechanisms for the management of BC, the role of their nanoparticles, and future novel therapies. The use of these compounds is not only a therapeutic practice for the conditions of bladder cancer, but it also upholds new avenues for creativity.

Indexed as

Biological ProductsMicroRNAsUrinary Bladder NeoplasmsAnimalsGene Expression Regulation, NeoplasticHumansBiological ProductsMicroRNAsBladder cancermiRNANanoparticlesNatural productsPathogenesis

Identifiers

PMID39883227

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.