Evidence map›Paper›PMID 39882766›Full record

ArticleFuture medicinal chemistry2025

Copper(II) complexes of 2-hydroxy-1-naphthaldehyde Schiff bases: synthesis,

Tanzeela Ahmad Shah, Aftab Alam, Zainab, Majid Khan, Ahmed A Elhenawy, Amalina Mohd Tajuddin, Muhammad Ayaz, Muhammad Said, Syed Adnan Ali Shah, Ajmal Khan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tanzeela Ahmad ShahDepartment of Chemistry, University of Malakand, Dir Lower, Khyber Pakhtunkhwa, Pakistan.
Aftab AlamDepartment of Chemistry, University of Malakand, Dir Lower, Khyber Pakhtunkhwa, Pakistan.ORCID 0000-0003-0475-2376
ZainabCollege of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang, China.
Majid KhanDepartment of Biochemistry, Hazara University, Mansehra, Pakistan.
Ahmed A ElhenawyChemistry Department, Faculty of Science, Al-Baha University, Al-Bahah, Saudi Arabia.ORCID 0000-0003-2893-0376
Amalina Mohd TajuddinAtta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam, Selangor, Malaysia.
Muhammad AyazDepartment of Chemistry, University of Malakand, Dir Lower, Khyber Pakhtunkhwa, Pakistan.
Muhammad SaidDepartment of Chemistry, University of Malakand, Dir Lower, Khyber Pakhtunkhwa, Pakistan.
Syed Adnan Ali ShahAtta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam, Selangor, Malaysia.ORCID 0000-0002-8142-5013
Ajmal KhanNatural and Medical Sciences Research Center, University of Nizwa, Nizwa, PC, Sultanate of Oman.ORCID 0000-0001-7590-5128
Abdul LatifDepartment of Chemistry, University of Malakand, Dir Lower, Khyber Pakhtunkhwa, Pakistan.
Mumtaz AliDepartment of Chemistry, University of Malakand, Dir Lower, Khyber Pakhtunkhwa, Pakistan.ORCID 0000-0001-7573-7953
Ahmed Al-HarrasiNatural and Medical Sciences Research Center, University of Nizwa, Nizwa, PC, Sultanate of Oman.ORCID 0000-0002-0815-5942
Manzoor AhmadDepartment of Chemistry, University of Malakand, Dir Lower, Khyber Pakhtunkhwa, Pakistan.ORCID 0000-0001-9736-5900

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDue to the divers biological applications of Cu(II) complexes, we in this study reports the various Cu(II) complexes. The study aims to synthesize and assess new Cu(II) complexes as powerful β-glucuronidase inhibitors.

methodsFive Schiff base ligands and their complexes were synthesized, characterized, and screened against β-glucuronidase inhibitory activity.

resultsIn the series, compounds 3e, 3c, 2b, and 2c ascribed powerful inhibition ranging from (IC

conclusionThe work recognizes latent active compounds for novel β-glucoronidase inhibitors, by further support these may be harnessed for the development of potent drugs.

Indexed as

Coordination ComplexesCopperEnzyme InhibitorsNaphthalenesHumansLigandsMolecular Docking SimulationMolecular StructureSchiff BasesStructure-Activity RelationshipCoordination ComplexesCopperEnzyme InhibitorsLigandsNaphthalenesSchiff Basescopper(ii)molecular dockingSchiff base ligandssingle crystal analysisβ-Glucuronidase

Identifiers

PMID39882766
PMCPMC11792854

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.