Evidence map›Paper›PMID 39882735›Full record

SynthesisFuture cardiology2025

Multivalvular vs single-valve infective endocarditis: a systematic review and meta-analysis.

Ioannis Kyriakoulis, Andreas Tzoumas, Konstantinos G Kyriakoulis, Ioannis Kardoutsos, Athina Ntoumaziou, Sanjana Nagraj, Damianos G Kokkinidis, Leonidas Palaiodimos

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Future cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ioannis KyriakoulisFaculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.ORCID 0000-0003-2970-088X
Andreas TzoumasDivision of Cardiovascular Health and Disease, University of Cincinnati Medical Center, Cincinnati, OH, USA.
Konstantinos G KyriakoulisSchool of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Ioannis KardoutsosFaculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Athina NtoumaziouDivision of Hematology, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Sanjana NagrajDivision of Cardiology, Montefiore Medical Center, Bronx, New York, NY, USA.ORCID 0000-0002-6230-7214
Damianos G KokkinidisHeart and Vascular Institute, Lawrence and Memorial Hospital, Northeast Medical Group, Yale New Haven Health, New London, CT, USA.
Leonidas PalaiodimosDepartment of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfective endocarditis is characterized by the colonization of heart valves by virulent microorganisms. It commonly manifests as involvement of a single heart valve -single-valve infective endocarditis (SIE), while in some patients, two or more heart valves are concomitantly infected -multivalvular infective endocarditis (MIE). The risk of complications and prognosis of MIE as opposed to SIE are unknown.

methodsWe performed a systematic search in MEDLINE and Scopus for studies of patients with MIE and SIE. The outcomes of interest included mortality, heart failure, systemic embolic events, and need for surgery.

resultsΟf 1,124 identified studies, eleven met the inclusion criteria. MIE was reported in 20.4% of the total patients. Compared to SIE, MIE was associated with increased risk of short-term mortality (RR: 1.29, 95% CI: 1.19-1.39), one-year mortality (RR: 1.20, 95% CI: 1.08-1.34), heart failure (RR: 1.31, 95% CI: 1.12-1.54), systemic embolic events (RR: 1.12, 95% CI: 1.02-1.22), and need for subsequent surgical management (RR: 1.22, 95% CI: 1.05-1.41).

conclusionsPatients with MIE have a higher likelihood of poor prognosis compared to patients with SIE. A high clinical suspicion of this condition and timely diagnosis and management are imperative while managing patients with infective endocarditis. PROTOCOL REGISTRATION: PROSPERO CRD42023486674.

Indexed as

EndocarditisEndocarditis, BacterialHeart Valve DiseasesHumansPrognosisBilateral infective endocarditisheart failureMortalitymultivalvular infective endocarditisSingle-valve infective endocarditissurgery for infective endocarditissystemic embolism

Identifiers

PMID39882735
PMCPMC11812418

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.