Evidence map›Paper›PMID 39882633›Full record

ArticleSpine2025

Defining Substantial Clinical Benefits of PROMIS Pain Interference and Physical Function in Patients Undergoing Lumbar and Thoracolumbar Spine Surgery.

Salim Yakdan, Madelyn R Frumkin, Saad Javeed, Benjamin A Plog, Justin K Zhang, Braeden Benedict, Kathleen Botterbush, Burel R Goodin, Jay F Piccirillo, Jacob M Buchowski and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Spine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Multidomain postoperative recovery trajectories after lumbar and thoracolumbar spine surgery.The spine journal : official journal of the North American Spine Society · 2025
    Observational
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Salim YakdanDepartment of Neurological Surgery, Washington University, St. Louis, MO, USA.ORCID 0009-0003-0109-5013
Madelyn R FrumkinDepartment of Psychological and Brain Sciences, Washington University, St. Louis, MO, USA.
Saad JaveedDepartment of Neurological Surgery, Washington University, St. Louis, MO, USA.
Benjamin A PlogDepartment of Neurological Surgery, Washington University, St. Louis, MO, USA.
Justin K ZhangDepartment of Neurological Surgery, Washington University, St. Louis, MO, USA.
Braeden BenedictDepartment of Neurological Surgery, Washington University, St. Louis, MO, USA.
Kathleen BotterbushDepartment of Neurological Surgery, Washington University, St. Louis, MO, USA.
Burel R GoodinDepartment of Anesthesiology, Washington University, St. Louis, MO, USA.
Jay F PiccirilloDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Jacob M BuchowskiDepartment of Orthopedic Surgery, Washington University, St. Louis, MO, USA.
Thomas L RodebaughDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill.
Wilson Z RayDepartment of Neurological Surgery, Washington University, St. Louis, MO, USA.
Michael P KellyDepartment of Orthopedic Surgery, Rady Children's Hospital, University of California, San Diego, CA, USA.
Jacob K GreenbergDepartment of Neurological Surgery, Washington University, St. Louis, MO, USA.

Funding

Using Mobile Health Technology and Real-Time Assessments to Address Multilevel Influences on Lumbar Spine Surgery OutcomesK23AR082986 · NIAMS · WASHINGTON UNIVERSITY · PI JACOB GREENBERG · 2024 to 2026
$515k
Personalized Models of Depression and Chronic PainF31MH124291 · NIMH · WASHINGTON UNIVERSITY · PI FRUMKIN, MADELYN · 2021 to 2022
$88k
NIAMS NIH HHS K23 AR082986NIMH NIH HHS F31 MH124291
6 · The paper itself

Abstract

STUDY

designProspective cohort study.

objectiveThis study aims to define Substantial Clinical Benefit (SCB) thresholds for PROMIS physical function (PF) and pain interference (PI) in lumbar or thoracolumbar spine surgery population. SUMMARY OF BACKGROUND DATA: Patient-reported outcome measures (PROMs) are widely used in spine surgery to assess treatment efficacy. SCB is a relatively new concept that represents a substantial improvement perceived by the patient.

methodsThis is a prospective study that included adults aged 21-85 years, undergoing lumbar/ thoracolumbar surgery for degenerative spine disease, and reporting at least 3/10 back or leg pain on a numeric rating scale. PROMs including Oswestry Disability Index, PROMIS PF, and PROMIS PI were collected preoperatively and at one year postoperatively. The North American Spine Surgery Patient Satisfaction (NASS) Index was collected one year postoperatively. SCB thresholds of absolute and percentage changes were calculated using anchor-based methods with ODI and NASS index as anchors. ROC analysis was used to determine optimal SCB cutoffs.

resultsWe included 137 patients. Using a fixed 19-point reduction in ODI as an anchor yielded SCB thresholds of 6.8 and 11.3 points for PROMIS PF and PI respectively. When using a dynamic anchor based on preoperative disability (50% ODI improvement), SCB thresholds were defined as achieving 18 and 27% of maximum possible improvement for PROMIS PF and PI respectively. Using NASS index, thresholds were 11 points or 24% for PROMIS PF, and 11.2 points or 21% for PROMIS PI. ROC values ranged from 0.81 to 0.9, with the dynamic ODI anchor cutoffs demonstrating the best discrimination.

conclusionOur study is the first to define SCB thresholds for PROMIS PF and PROMIS PI using both fixed and dynamic cutoffs based on preoperative disability in lumbar and thoracolumbar patients. These thresholds will help in patient counseling and outcome evaluation for spine surgery research.

Identifiers

PMID39882633
PMCPMC12307724

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.