Evidence map›Paper›PMID 39882626›Full record

Trial reportStroke2025

Effect of Remote Ischemic Conditioning on the Form and Function of Red Blood Cells in Patients With Acute Ischemic Stroke.

Rolf Ankerlund Blauenfeldt, Jennifer Waller, Kim Ryun Drasbek, Jesper Nørgaard Bech, Anne-Mette Hvas, Julie Brogaard Larsen, Morten Nørgaard Andersen, Marlene Christina Nielsen, Maria Kjølhede, Mathilde Kjeldsen and 5 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03481777 (Remote Ischemic Conditioning in Patients With Acute Stroke), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03481777 nacompletednot on this map

Remote Ischemic Conditioning in Patients With Acute Stroke: a Multicenter Randomized, Patient-assessor Blinded, Sham-controlled Study

TypeinterventionalSponsorGrethe AndersenRan2018 to 2023Enrolled1,500ConditionsStroke, Acute, Ischemic Stroke, Hemorrhagic Stroke, Intracerebral HemorrhageArmsRemote Ischemic Conditioning, Sham Remote Ischemic Conditioning
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rolf Ankerlund BlauenfeldtDepartment of Neurology (R.A.B., M. Kjølhede, G.A.), Aarhus University Hospital, Denmark.ORCID 0000-0002-4846-9516
Jennifer WallerDepartment of Family and Community Medicine (J.W.), Medical College of Georgia, Augusta University.ORCID 0000-0003-4066-4541
Kim Ryun DrasbekCenter for Functionally Integrative Neuroscience (K.R.D.), Aarhus University, Denmark.ORCID 0000-0003-2701-2741
Jesper Nørgaard BechDepartment of Clinical Medicine (R.A.B., J.N.B., M.N.A., M.F.G., G.A.), Aarhus University, Denmark.ORCID 0000-0002-0605-1277
Anne-Mette HvasCenter for Thrombosis and Hemostasis, Department of Clinical Biochemistry (A.-M.H., J.B.L., M.C.N.), Aarhus University Hospital, Denmark.ORCID 0000-0002-7136-7534
Julie Brogaard LarsenCenter for Thrombosis and Hemostasis, Department of Clinical Biochemistry (A.-M.H., J.B.L., M.C.N.), Aarhus University Hospital, Denmark.
Morten Nørgaard AndersenDepartment of Hematology (M.N.A.), Aarhus University Hospital, Denmark.ORCID 0000-0003-0820-7789
Marlene Christina NielsenCenter for Thrombosis and Hemostasis, Department of Clinical Biochemistry (A.-M.H., J.B.L., M.C.N.), Aarhus University Hospital, Denmark.ORCID 0000-0003-2008-4224
Maria KjølhedeDepartment of Neurology (R.A.B., M. Kjølhede, G.A.), Aarhus University Hospital, Denmark.ORCID 0000-0003-1544-6104
Mathilde KjeldsenUniversity Clinic in Nephrology and Hypertension, Gødstrup Regional Hospital, Herning, Denmark (J.N.B., M. Kjeldsen).
Martin Faurholdt GudeDepartment of Clinical Medicine (R.A.B., J.N.B., M.N.A., M.F.G., G.A.), Aarhus University, Denmark.ORCID 0000-0003-2888-1842
Mohammad Badruzzaman KhanDepartment of Neurology (M.B.K., B.B., D.C.H.), Medical College of Georgia, Augusta University.ORCID 0000-0001-8231-1256
Babak BabanDepartment of Neurology (M.B.K., B.B., D.C.H.), Medical College of Georgia, Augusta University.ORCID 0000-0002-3144-2288
Grethe AndersenDepartment of Neurology (R.A.B., M. Kjølhede, G.A.), Aarhus University Hospital, Denmark.ORCID 0000-0001-6807-2500
David Charles HessDepartment of Neurology (M.B.K., B.B., D.C.H.), Medical College of Georgia, Augusta University.ORCID 0000-0002-8345-9153

Funding

Rheoerythrocrine dysfunction in stroke and remote ischemic conditioning (REDS)R01NS112511 · NINDS · AUGUSTA UNIVERSITY · PI HESS, DAVID C. · 2020 to 2023
$1.3M
Targeting RBC dysfunction in VCIDR01NS122863 · NINDS · AUGUSTA UNIVERSITY · PI HESS, DAVID C. · 2024 to 2025
$1.0M
NINDS NIH HHS R01 NS112511NINDS NIH HHS R01 NS122863
6 · The paper itself

Abstract

backgroundRemote ischemic conditioning (RIC) is a simple and low-cost intervention that is thought to increase collateral blood flow through the vasodilatory effects of nitric oxide (NO) produced by the endothelium and red blood cells (RBCs). This study aims to investigate whether RIC affects RBC deformability and levels of NO and nitrite in patients with ischemic stroke.

methodsThis is a predefined substudy to the RESIST (Remote Ischemic Conditioning in Patients With Acute Stroke Trial) randomized clinical trial conducted in Denmark. RIC was started in the ambulance and continued at the hospital for seven days. Blood samples were collected at different time points: prehospital in the ambulance, in-hospital upon arrival, 2 hours postadmission, and 24 hours postadmission. RBC deformability and erythrocyte aggregation rate were assessed using ektacytometry, NO using flowcytometry, and nitrite content using ozone chemiluminescence.

resultsOf 1500 prehospital randomized patients, 486 patients were included in this study between July 28, 2020, and November 11, 2023, and had blood samples taken. Of these, 249 (51%) had AIS, and here RIC treatment was not associated with increased RBC maximal deformability (RIC, 0.549; sham, 0.548;

conclusionsPrehospital and in-hospital RIC significantly reduced erythrocyte aggregation rate in patients with acute ischemic stroke, while there was no change in RBC deformability, NO content, or whole blood nitrite levels. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03481777.

Indexed as

Erythrocyte DeformabilityErythrocytesIschemic PreconditioningIschemic StrokeAgedAged, 80 and overDenmarkErythrocyte AggregationFemaleHumansMaleMiddle AgedNitric OxideNitritesProspective StudiesNitric OxideNitriteserythrocytesischemic strokenitric oxidenitrites

Identifiers

PMID39882626
PMCPMC11850200

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.