Evidence map›Paper›PMID 39882543›Full record

ArticleResearch (Washington, D.C.)2023

Reversibly Tuning Electrochemiluminescence with Stimulated Emission Route for Single-Cell Imaging.

Cheng Ma, Xiaodan Gou, Zejing Xing, Min-Xuan Wang, Wenlei Zhu, Qin Xu, Dechen Jiang, Jun-Jie Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cheng MaSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China.
Xiaodan GouState Key Laboratory of Analytical Chemistry for Life Science, State Key Laboratory of Pollution Control and Resource Reuse, School of Chemistry and Chemical Engineering, School of the Environment, Nanjing University, Nanjing 210023, P. R. China.
Zejing XingState Key Laboratory of Analytical Chemistry for Life Science, State Key Laboratory of Pollution Control and Resource Reuse, School of Chemistry and Chemical Engineering, School of the Environment, Nanjing University, Nanjing 210023, P. R. China.
Min-Xuan WangState Key Laboratory of Analytical Chemistry for Life Science, State Key Laboratory of Pollution Control and Resource Reuse, School of Chemistry and Chemical Engineering, School of the Environment, Nanjing University, Nanjing 210023, P. R. China.
Wenlei ZhuState Key Laboratory of Analytical Chemistry for Life Science, State Key Laboratory of Pollution Control and Resource Reuse, School of Chemistry and Chemical Engineering, School of the Environment, Nanjing University, Nanjing 210023, P. R. China.
Qin XuSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China.
Dechen JiangState Key Laboratory of Analytical Chemistry for Life Science, State Key Laboratory of Pollution Control and Resource Reuse, School of Chemistry and Chemical Engineering, School of the Environment, Nanjing University, Nanjing 210023, P. R. China.ORCID https://orcid.org/0000-0002-8201-1285
Jun-Jie ZhuState Key Laboratory of Analytical Chemistry for Life Science, State Key Laboratory of Pollution Control and Resource Reuse, School of Chemistry and Chemical Engineering, School of the Environment, Nanjing University, Nanjing 210023, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrochemiluminescence (ECL) has established itself as an excellent transduction technique in biosensing and light-emitting device, while conventional ECL mechanism depending on spontaneous emission of luminophores lacks reversibility and tunable emission characters, limiting the universality of ECL technique in the fields of fundamental research and clinical applications. Here, we report the first observation of stimulated emission route in ECL and thus establish a reversible tuning ECL microscopy for single-cell imaging. This microscopy uses a focused red-shifted beam to transfer spontaneous ECL into stimulated ECL, which enables selective and reversible tuning of ECL emission from homogeneous solution, single particles, and single cells. After excluding other possible competitive routes, the stimulated ECL emission route is confirmed by a dual-objective system in which the suppressed spontaneous ECL is accompanied by the enhanced stimulated ECL. By incorporating a commercial donut-shaped beam, the sharpness of single-cell matrix adhesion is improved 2 to 3 times compared with the counterpart in confocal ECL mode. The successful establishment of this stimulated emission ECL will greatly advance the development of light-emitting device and super-resolution ECL microscopy.

Identifiers

PMID39882543
PMCPMC11776023

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