ArticleFrontiers in medicine2024
Difference between estimated glomerular filtration rate based on cystatin C versus creatinine and cardiovascular-kidney-metabolic health.
Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Cystatin C-creatinine eGFR discordance and all-cause mortality in adults with preserved creatinine-based kidney function: a dual-cohort study.International urology and nephrology · 2026Article
- Cardiovascular-Kidney-Metabolic Syndrome: A New Paradigm in Clinical Medicine or Going Back to Basics?Journal of clinical medicine · 2025Review
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Authors and funding
8 authors.
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Abstract
Background: The difference between the estimated glomerular filtration rate (eGFR) calculated from cystatin C and creatinine (eGFRdiff) serves as a biomarker of kidney function impairment. However, the role of eGFRdiff in cardiovascular-kidney-metabolic (CKM) health and its impact on mortality in CKM syndrome patients has not yet been studied. Methods: This study included 3,622 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2004. Weighted ordinal logistic regression was used to explore the link between eGFRdiff and CKM health, while weighted Cox regression was used to examine the relationship between eGFRdiff and mortality in CKM syndrome patients. Restricted cubic splines (RCSs) were used to analyze the dose-response relationship. Results: The common odds ratio (cOR) per 10 mL/min/1.73m Conclusion: Our study found that eGFRdiff is associated with CKM health and stratified mortality risk in CKM syndrome patients.
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