ArticleWellcome open research2024
Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study.
Article in Wellcome open research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Home-learning environment and cognitive and academic outcomes among children aged 4-8 years: A cross-sectional study from South India.Dialogues in health · 2025Article
- Latent profile of alexithymia in Chinese nursing students and its relationship with anxiety, depression, and stress: a cross-sectional study.BMC medical education · 2025Article
- It Takes a Village: Unpacking Contextual Factors Influencing Caregiving in Urban Poor Neighbourhoods of Bangalore, South India.Healthcare (Basel, Switzerland) · 2025Article
- A non-specialist worker delivered digital assessment of cognitive development (DEEP) in young children: A longitudinal validation study in rural India.PLOS digital health · 2025Article
- Examining characteristics of father-child relationship: A qualitative scoping review protocol.Wellcome open research · 2025Article
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Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Background: Over 250 million children are developing sub-optimally due to their exposure to early life adversities. While previous studies have examined the Objectives: This study aims to investigate the independent, interaction, and cumulative effects of nutritional, psychosocial, and environmental factors on children's cognitive development and mental health in urban and rural India. It also seeks to explain pathways leading to inequities in child outcomes at the individual, household, and neighbourhood levels. Methods: A mixed-methods prospective cohort study will be conducted on 1600 caregiver-child dyads (child age 3-10 years) in urban and rural India. Nutritional status, psychosocial adversities, environmental pollutants, and child mental health outcomes will be assessed using parent-report questionnaires. Performance-based measures will be used to assess cognitive outcomes. Venous blood and urine samples will be used to measure nutritional and pesticide biomarkers in 500 children. Indoor air pollution will be monitored in 200 households twice, during two seasons. Multilevel regression, weighted quantile sum regression, and Bayesian kernel machine regression will assess the individual and combined effects of exposures on child outcomes. Thematic analysis of in-depth interviews and focus group discussions will explore pathways to middle-and late childhood development inequities. Discussion: The data will be used to formulate a Theory of Change (ToC) to explain the biological, psychosocial, and environmental origins of children's cognitive and mental health outcomes across the first decade of life in diverse Indian settings, which can inform interventions targets for promoting children's outcomes beyond the first 1000 days, potentially generalizable to similar under-resourced global settings. The COINCIDE research infrastructure will comprise a valuable global health resource, including prospective cohort data, validated study tools, and stored biological and environmental samples for future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.