Evidence map›Paper›PMID 39882327›Full record

ArticleFrontiers in physiology2024

Chronic fetal hypoxia and antenatal Vitamin C exposure differentially regulate molecular signalling in the lung of female lambs in early adulthood.

Erin V McGillick, Sandra Orgeig, Beth J Allison, Kirsty L Brain, Melanie R Bertossa, Stacey L Holman, Ashley S Meakin, Michael D Wiese, Youguo Niu, Nozomi Itani and 5 more

Abstract read
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In one paragraph

Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Erin V McGillickEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, University of South Australia, Adelaide, Australia.
Sandra OrgeigClinical and Health Sciences, University of South Australia, Adelaide, Australia.
Beth J AllisonDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Kirsty L BrainDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Melanie R BertossaEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, University of South Australia, Adelaide, Australia.
Stacey L HolmanEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, University of South Australia, Adelaide, Australia.
Ashley S MeakinEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, University of South Australia, Adelaide, Australia.
Michael D WieseClinical and Health Sciences, University of South Australia, Adelaide, Australia.
Youguo NiuDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Nozomi ItaniDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Katie L SkeffingtonDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Christian BeckDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Kimberly J Botting-LawfordDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Janna L Morrison *Early Origins of Adult Health Research Group, Health and Biomedical Innovation, University of South Australia, Adelaide, Australia.
Dino A Giussani *Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Chronic fetal hypoxia is commonly associated with fetal growth restriction and can predispose to respiratory disease at birth and in later life. Antenatal antioxidant treatment has been investigated to overcome the effects of oxidative stress Methods: Chronically catheterised pregnant sheep were exposed to normoxia (N; n = 20) or hypoxia (H; n = 18; 10% O Results: Chronic fetal hypoxia upregulated lung expression of markers of prooxidant, surfactant lipid transport and airway remodelling pathways in early adulthood. Antenatal Vitamin C normalized prooxidant and airway remodelling markers, increased endogenous antioxidant, vasodilator and inflammatory markers, and altered regulation of hypoxia signalling and glucocorticoid availability. Conclusion: There are differential effects of antenatal Vitamin C on molecular markers in the lungs of female lambs from normoxic and hypoxic pregnancy in early adulthood.

Indexed as

antenatal antioxidantchronic fetal hypoxialungmolecularpostnatalVitamin C

Identifiers

PMID39882327
PMCPMC11775154

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.