Evidence map›Paper›PMID 39882239›Full record

ArticleFrontiers in immunology2024

A conserved element in the first intron of

Gregory A Swan, Chika Fujii, Mia E Guzynski, Sheridan M Page, Isabelle V Meyers, Yordan P Penev, Sejiro Littleton, Adinda Azzahra, Christine Richardson, Sophia D Sarafova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gregory A SwanIntegrative Immunobiology Department, Duke University, Durham, NC, United States.
Chika FujiiBiology Department, Davidson College, Davidson, NC, United States.
Mia E GuzynskiBiology Department, Davidson College, Davidson, NC, United States.
Sheridan M PageBiology Department, Davidson College, Davidson, NC, United States.
Isabelle V MeyersBiology Department, Davidson College, Davidson, NC, United States.
Yordan P PenevBiology Department, Davidson College, Davidson, NC, United States.
Sejiro LittletonIntegrative Immunobiology Department, Duke University, Durham, NC, United States.
Adinda AzzahraBiology Department, Davidson College, Davidson, NC, United States.
Christine RichardsonDepartment of Biological Sciences, University of North Carolina-Charlotte, Charlotte, NC, United States.
Sophia D SarafovaIntegrative Immunobiology Department, Duke University, Durham, NC, United States.

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Identification and functional characterization of a novel positive cis-control elR15AI098001 · NIAID · DAVIDSON COLLEGE · PI SARAFOVA, SOPHIA DORCHEVA · 2013 to 2013
$408k
NCATS NIH HHS UL1 TR002378NIAID NIH HHS R15 AI098001
6 · The paper itself

Abstract

Introduction: The regulation of Methods: To investigate the role of NCE, transient transfection of reporter plasmids was performed in thymoma cell lines arrested at the double-positive (DP, CD4 Results: Our Discussion: This study demonstrates that the canonical enhancer function of coreNCE/E4m is essential for CD4 upregulation following positive selection. The NCE region, with its developmental-stage-specific activity and its known epigenetic regulatory capabilities, ensures faithful lineage commitment to the CD4 lineage.

Indexed as

CD4 AntigensCD4-Positive T-LymphocytesCell LineageEnhancer Elements, GeneticIntronsReceptors, Antigen, T-CellAnimalsCell Line, TumorConserved SequenceMiceMice, TransgenicSignal TransductionThymocytesUp-RegulationCD4 AntigensReceptors, Antigen, T-CellCD4enhancer functionhelper T-cell lineageT-cell developmenttranscriptional regulation

Identifiers

PMID39882239
PMCPMC11774700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.