Evidence map›Paper›PMID 39882220›Full record

ArticleJournal of the anus, rectum and colon2025

Factors Affecting the Prognosis after Primary Tumor Resection for Patients with Metastatic Colorectal Cancer with Synchronous Peritoneal Metastasis: A Multi-center, Prospective, Observational Study.

Satoru Kagami, Kimihiko Funahashi, Hirotoshi Kobayashi, Kenjiro Kotake, Masayasu Kawasaki, Yusuke Kinugasa, Hideki Ueno, Kotaro Maeda, Takeshi Suto, Michio Itabashi and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the anus, rectum and colon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Satoru KagamiDepartment of General and Gastroenterological Surgery, Toho University Omori Medical Center, Tokyo, Japan.
Kimihiko FunahashiDepartment of General and Gastroenterological Surgery, Toho University Omori Medical Center, Tokyo, Japan.
Hirotoshi KobayashiDepartment of Surgery, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan.
Kenjiro KotakeDepartment of Surgery, Sano City Hospital, Tochigi, Japan.
Masayasu KawasakiDepartment of Surgery, Bell Land General Hospital, Sakai, Japan.
Yusuke KinugasaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.
Hideki UenoDepartment of Surgery, National Defense Medical College, Tokorozawa, Japan.
Kotaro MaedaInternational Medical Center, Fujita Health University Hospital, Toyoake, Japan.
Takeshi SutoDepartment of Gastroenterological Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan.
Michio ItabashiDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Heita OzawaDepartment of Surgery, Tochigi Cancer Center, Utsunomiya, Japan.
Fumikazu KoyamaDepartment of Surgery, Nara Medical University, Kashihara, Japan.
Shingo NouraDepartment of Surgery, Osaka Rosai Hospital, Sakai, Japan.
Hideyuki IshidaDepartment of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Masayuki OhueDepartment of Gastroenterological Surgery, Osaka International Cancer Institute, Osaka, Japan.
Tomomichi KiyomatsuDepartment of Colorectal Surgery, National Center for Global Health and Medicine, Tokyo, Japan.
Soichiro IshiharaDepartment of Surgical Oncology, The University of Tokyo Hospital, Tokyo, Japan.
Keiji KodaDepartment of Surgery, Teikyo University Chiba Medical Center, Ichihara, Japan.
Hideo BabaDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Kenji KawadaDepartment of Gastrointestinal Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yojiro HashiguchiDepartment of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
Takanori GoiFirst Department of Surgery, University of Fukui, Fukui, Japan.
Yuji ToiyamaDepartment of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan.
Naohiro TomitaDivision of Lower Gastrointestinal Surgery, Department of Gastroenterological Surgery, Hyogo Medical University, Hyogo, Japan.
Eiji SunamiDepartment of Surgery, Kyorin University School of Medicine, Tokyo, Japan.
Fumihiko FujitaDepartment of Surgery, Kurume University School of Medicine, Kurume, Japan.
Jun WatanabeDepartment of Colorectal Surgery, Kansai Medical University, Osaka, Japan.
Kenichi HakamadaDepartment of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Aomori, Japan.
Goro NakayamaDepartment of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kenichi SugiharaInstitute of Science Tokyo, Tokyo, Japan.
Yoichi AjiokaDivision of Molecular and Diagnostic Pathology, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To clarify the risk factors affecting prognosis after primary tumor resection (PTR) in patients with metastatic colorectal cancer with synchronous peritoneal metastasis (mCRC-SPM). Methods: Patients were enrolled prospectively in the JSCCR project "Grading of Peritoneal Seeding in Colorectal Cancer." Factors that may influence overall survival-age, sex, location of the primary tumor, lymph node metastasis, presence of liver metastasis, degree of peritoneal metastasis, peritoneal cancer index (PCI), cancer cure, and postoperative chemotherapy-in the PTR group were examined using multivariate analysis. Results: Of the 133 enrolled patients with mCRC-SPM, 112 patients underwent PTR. Among them, 26 (23.2%) had mCRC-SPM of grade P1, 47 (42.0%) of P2, and 39 (34.8%) of P3. The median PCI was 4 (range, 1-28); no surgery-related deaths occurred. Postoperative complications of Clavien-Dindo classification ≥grade 2 were observed in 20 (17.9%) patients. R0 surgery became more difficult as the degree of dissemination increased, and the PTR group had a significantly better prognosis than the non-PTR group. In the multivariate analysis, age ≥75 years, rectal cancer, presence of liver metastasis, higher PCI, non-curative resection, and non-treatment with systemic chemotherapy were associated with poor prognosis in patients after PTR. Conclusions: In patients with mCRC-SPM, postoperative complications are infrequent for P1 with localized peritoneal dissemination, and PTR may be considered as aggressive treatment. Factors including age ≥75 years, rectal cancer, presence of liver metastasis, increased PCI, non-curative resection, and non-treatment with systemic chemotherapy are associated with a reduced survival benefit from PTR.

Indexed as

colorectal cancerprimary tumor resectionprognosissynchronous peritoneal metastasis

Identifiers

PMID39882220
PMCPMC11772787

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.