Evidence map›Paper›PMID 39882207›Full record

ArticleFrontiers in pediatrics2024

Case Report: Hypercalcemia, subcutaneous fat necrosis and nephrocalcinosis in neonates who undergo therapeutic hypothermia: a not so rare association, with different onset time.

Domenico Umberto De Rose, Chiara Maddaloni, Guglielmo Salvatori, Francesca Campi, Antonio Gatto, Ludovica Martini, Immacolata Savarese, Iliana Bersani, Graziamaria Ubertini, Francesca Serrao and 5 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Domenico Umberto De Rose *Neonatal Intensive Care Unit, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Chiara Maddaloni *Neonatal Intensive Care Unit, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Guglielmo SalvatoriNeonatal Intensive Care Unit, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Francesca CampiNeonatal Intensive Care Unit, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Antonio GattoInstitute of Pediatrics, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy.
Ludovica MartiniNeonatal Intensive Care Unit, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Immacolata SavareseNeonatal Intensive Care Unit, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Iliana BersaniNeonatal Intensive Care Unit, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Graziamaria UbertiniPediatric Endocrinology Unit, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Francesca SerraoNeonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy.
Simonetta CostaNeonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy.
Annabella BragugliaNeonatal Sub-Intensive Care Unit and Follow-up, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Francesca GalliniUniversità Cattolica del Sacro Cuore, Rome, Italy.
Giovanni VentoNeonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy.
Andrea DottaNeonatal Intensive Care Unit, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subcutaneous fat necrosis (SCFN) in newborns is an uncommon and self-limiting non-infectious panniculitis. It can occur in the first weeks of life in full-term newborns with hypoxic-ischemic encephalopathy who underwent therapeutic hypothermia. Hypercalcemia may develop and has been implicated as the cause of several complications as nephrocalcinosis. Hypercalcemia has been previously reported to appear only after resolution of skin lesions. Herein, we report how hypercalcemia can be evident already at diagnosis of subcutaneous fat necrosis after therapeutic hypothermia and can be associated with an early onset developing nephrocalcinosis. We compare two cases of these uncommon findings and review the recent literature.

Indexed as

critical care medicinehypercalcemiahypoxic-ischemic encephalopathyneonatenephrocalcinosistherapeutic hypothermia

Identifiers

PMID39882207
PMCPMC11774902

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.