Evidence map›Paper›PMID 39882026›Full record

ArticleBrain communications2025

Theta and beta power in the subthalamic nucleus responds to conflict across subregions and hemispheres.

Jessica L Bowersock, Scott A Wylie, Ahmad Alhourani, Ajmal Zemmar, Victoria Holiday, Peter Hedera, Travis Stewart, Elizabeth Bridwell, Isabelle Hattab, Beatrice Ugiliweneza and 2 more

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jessica L BowersockDepartment of Neurological Surgery, University of Louisville, Louisville, KY 40202, USA.ORCID https://orcid.org/0000-0002-0577-1184
Scott A WylieDepartment of Neurological Surgery, University of Louisville, Louisville, KY 40202, USA.
Ahmad AlhouraniDepartment of Neurological Surgery, University of Louisville, Louisville, KY 40202, USA.
Ajmal ZemmarDepartment of Neurological Surgery, University of Louisville, Louisville, KY 40202, USA.
Victoria HolidayDepartment of Neurology, University of Louisville Health, Louisville, KY 40202, USA.
Peter HederaDepartment of Neurology, University of Louisville Health, Louisville, KY 40202, USA.
Travis StewartDepartment of Neurological Surgery, University of Louisville, Louisville, KY 40202, USA.
Elizabeth BridwellDepartment of Neurological Surgery, University of Louisville, Louisville, KY 40202, USA.
Isabelle HattabDepartment of Neurological Surgery, University of Louisville, Louisville, KY 40202, USA.ORCID https://orcid.org/0009-0006-8999-6570
Beatrice UgiliwenezaDepartment of Neurological Surgery, University of Louisville, Louisville, KY 40202, USA.ORCID https://orcid.org/0000-0001-7334-6924
Joseph S NeimatDepartment of Neurological Surgery, University of Louisville, Louisville, KY 40202, USA.
Nelleke C van WouweDepartment of Neurological Surgery, University of Louisville, Louisville, KY 40202, USA.

Funding

Modulating Inhibitory Action Control Systems With Subthalamic Nucleus StimulationR01NS100996 · NINDS · UNIVERSITY OF LOUISVILLE · PI NEIMAT, JOSEPH S, VAN WOUWE, NELLEKE C. · 2018 to 2022
$1.7M
NINDS NIH HHS R01 NS100996
6 · The paper itself

Abstract

The subthalamic nucleus is thought to play a crucial role in controlling impulsive actions. Networked among the basal ganglia and receiving input from several cortical areas, the subthalamic nucleus is well positioned to influence action selection when faced with competing and conflicting action outcomes. The purpose of this study was to test the dissociable roles of the dorsal and ventral aspects of the subthalamic nucleus during action conflict in patients with Parkinson's disease undergoing intraoperative neurophysiological recording and to explore a potential mechanism for this inhibitory control. We hypothesized that modulations of neurophysiological activity during action conflict would be more pronounced in the dorsal subthalamic nucleus compared with the ventral subthalamic nucleus, due to the dissociation of cortical afferents to subthalamic nucleus subregions and previous findings of deep brain stimulation targeting subthalamic nucleus subregions in Parkinson's disease. We recorded neurophysiological activity while 10 participants with Parkinson's disease performed the Simon task during deep brain stimulation surgery. Response-locked local field potentials in the theta and beta band (associated with conflict control and movement inhibition, respectively) were analysed across subthalamic nucleus subregions and hemispheres relative to the motor response (ipsilateral/contralateral). In the presence of action conflict, the dorsal subthalamic nucleus, connected to cortical motor regions, exhibited larger theta power relative to the ventral subthalamic nucleus subregion, which is linked to the limbic circuits (

Indexed as

conflict controllocal field potentialssubthalamic nucleus

Identifiers

PMID39882026
PMCPMC11775628

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.