ArticleJournal of biomedical optics2025
Enhanced porphyrin-based hypoxia imaging by temporal oversampling of delayed fluorescence signal.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Intracellular oxygen measurement in vivo by smartphone readout of endogenous Protoporphyrin IX delayed fluorescence.Biosensors & bioelectronics · 2026Article
- Imaging lymphatic function and inflammation response through hypoxia via endogenous biomarker.Journal of biomedical optics · 2026Article
- ALA-based photodynamic priming in murine skin increases blood flow and oxygenation.Journal of biomedical optics · 2025Article
- Emerging uses of 5-aminolevulinic-acid-induced protoporphyrin IX in medicine: a review of multifaceted, ubiquitous, molecular diagnostic, therapeutic, and theranostic opportunities.Journal of biomedical optics · 2025Review
- Introduction to Special Issue on Metabolic Imaging and Spectroscopy, 2025.Journal of biomedical optics · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Significance: Protoporphyrin IX (PpIX) delayed fluorescence (DF) is inversely related to the oxygen present in tissues and has potential as a novel biomarker for surgical guidance and real-time tissue metabolism assessment. Despite the unique promise of this technique, its successful clinical translation is limited by the low intensity emitted. Aim: We developed a systematic study of ways to increase the PpIX DF signal through acquisition sampling changes, allowing optimized imaging at video rates. Approach: To accomplish signal increase, time-gating signal compression was achieved through changes in pulse frequency and power density, using sampling rates that are faster than the decay rate of the signal. The increased signal yield was tested and validated Results: Results Conclusions: The proposed timing optimization enhances PpIX-based DF real-time imaging of tissue hypoxia. By increasing sampling frequency and adjusting the acquisition gate and pulse width, the collected signal intensity improved sevenfold, demonstrated both
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.