ArticleNature and science of sleep2025
Causal Association Between Obstructive Sleep Apnea and Migraine: A Bidirectional Mendelian Randomization Study.
Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Goldenhar Syndrome-Embryological, Anatomical, Etiopathogenic Mechanisms and Treatment of Obstructive Sleep Apnea.International journal of molecular sciences · 2026Review
- Unveiling new insights into migraine risk stratification using machine learning models of adjustable risk factors.The journal of headache and pain · 2025Article
- Enhancing the Robustness of MR Analysis on OSA and Migraine: Addressing Key Limitations [Letter].Nature and science of sleep · 2025Article
- Enhancing the Robustness of MR Analysis on OSA and Migraine: Addressing Key Limitations [Response to Letter].Nature and science of sleep · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Patients with obstructive sleep apnea (OSA) frequently suffer from migraine, however the causal relationship between OSA and migraine is unknown. Investigating the causation will assist in understanding the etiology of OSA and migraine. Methods: Bidirectional two-sample Mendelian randomization (MR) and multivariable MR (MVMR) approaches were carried out to investigate the causal link between OSA and migraine. The public genome-wide association study (GWAS) data for OSA, migraine, and subtypes were obtained from the IUE open GWAS project and the FinnGen consortium. To investigate the causal links between OSA and migraine, inverse variance weighted (IVW) analysis was used in conjunction with four additional statistical approaches. Furthermore, sensitivity studies were performed using heterogeneity and pleiotropy tests to assess the estimation's robustness. Results: In general, our findings suggested that the OSA is causally associated with migraine with aura (MA, IVW: OR = 1.147; 95% CI = 1.016-1.295; P = 0.026), which was confirmed with the MVMR analysis further (OR = 1.184, 95% CI = 1.028-1.364, P = 0.020). In addition, increased risk of migraine and migraine without aura on OSA occurrence were identified in the reverse analysis, but these results were subsequently negated with MVMR analysis. Conclusion: According to the current findings, there was a preliminary causal effect of OSA on MA among European descendants. Clinical Relevance: These findings suggest a potential causal effect of OSA on migraine and provide new insights to prevent and manage the two disorders.
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