Evidence map›Paper›PMID 39881817›Full record

ArticleBrain, behavior, & immunity - health2024

The potential role of interleukin-6 in the association between inflammation and cognitive performance in obstructive sleep apnea.

Mariana Fernandes, Matteo Spanetta, Giorgio Vetrugno, Marzia Nuccetelli, Fabio Placidi, Alessandro Castelli, Natalia Manfredi, Francesca Izzi, Giuseppina Laganà, Sergio Bernardini and 2 more

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Article in Brain, behavior, & immunity - health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mariana FernandesDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133, Rome, Italy.
Matteo SpanettaSanta M. Della Stella Hospital, Orvieto, Italy.
Giorgio VetrugnoDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133, Rome, Italy.
Marzia NuccetelliDepartment of Clinical Biochemistry and Molecular Biology, University of Rome "Tor Vergata", Rome, Italy.
Fabio PlacidiDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133, Rome, Italy.
Alessandro CastelliSleep Medicine Centre, Neurology Unit, University Hospital of Rome "Tor Vergata", 00133, Rome, Italy.
Natalia ManfrediDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133, Rome, Italy.
Francesca IzziSleep Medicine Centre, Neurology Unit, University Hospital of Rome "Tor Vergata", 00133, Rome, Italy.
Giuseppina LaganàDepartment of Orthodontics, Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", 00133, Rome, Italy.
Sergio BernardiniDepartment of Clinical Biochemistry and Molecular Biology, University of Rome "Tor Vergata", Rome, Italy.
Nicola Biagio MercuriDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133, Rome, Italy.
Claudio LiguoriDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Interleukin-6 (IL-6) represents one of the main molecules involved in inflammatory responses, which can be altered in either patients with cognitive impairment or obstructive sleep apnea (OSA). The present study aimed to evaluate serum IL-6 levels and cognitive performance in patients with severe OSA (Apnea-Hypopnea Index - AHI >30/h). Methods: Thirty patients with severe OSA were compared to 15 controls similar in age, sex, and Body Mass Index. All patients underwent a sleep medicine interview, including the Epworth Sleepiness Scale (ESS), a polygraphic cardiorespiratory recording, the Montreal Cognitive Assessment (MoCA), and a blood sample for serum IL-6 assessment. Results: OSA patients presented higher IL-6 serum levels (Md = 7.38) than controls (Md = 2.20, p < 0.001). Moreover, OSA patients showed lower MoCA (Md = 27.00) and higher ESS scores (Md = 8.00) than controls (Md = 30.00, p < 0.001; Md = 4.00, p = 0.004, respectively). Higher IL-6 serum levels were associated with lower oxygen saturation parameters and MoCA scores. Conclusions: This study documented an association between inflammation, featured by higher IL-6 serum levels, and both nocturnal hypoxemia and cognitive impairment in OSA patients. Therefore, the increase in IL-6 levels may represent the result of vascular damage and neuroinflammation due to intermittent nocturnal hypoxia and further causing neurocognitive dysfunction in OSA.

Indexed as

Cognitive impairmentCytokinesExcessive daytime sleepinessIntermittent hypoxiaNeuroinflammationSleep-disordered breathing

Identifiers

PMID39881817
PMCPMC11776075

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.