Observational studyJournal of the International Society of Sports Nutrition2025
Is lean mass quantity or quality the determinant of maximal fat oxidation capacity? The potential mediating role of cardiorespiratory fitness.
Observational study in Journal of the International Society of Sports Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Optimizing Metabolic Assessment: Maximal Fat Metabolism, Lactate Dynamics, and Cardiorespiratory Determinants at Different Pedaling Frequencies.Journal of diabetes research · 2026Trial
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Authors and funding
9 authors.
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Abstract
backgroundImpaired fat oxidation is linked to cardiometabolic risk. Maximal fat oxidation rate (MFO) reflects metabolic flexibility and is influenced by lean mass, muscle strength, muscle quality - defined as the ratio of strength to mass - and cardiorespiratory fitness. The relationship between these factors and fat oxidation is not fully understood. The aim is to analyze the associations of lean-mass, muscle strength and quality with fat oxidation parameters in young adults, considering the mediating role of VO
methodsA cross-sectional observational study. Eighty-one adults (50 males, 31 females; age 22.8 ± 4.4, BMI 25.70 ± 5.75, lean-mass 54.19 ± 8.78, fat-mass 18.66 ± 11.32) Body composition assessment by bioimpedance determine fat and lean-mass. Indirect calorimetry at rest and exercise was used for the calculation of fat oxidation. An incremental exercise protocol in a cycle ergometer with two consecutive phases was performed. The first to determine MFO consisted of 3 min steps of 15W increments with a cadence of 60rpm. The test was stopped when RQ ≥ 1. After 5 min rest, a phase to detect VO
resultsTotal lean-mass and leg lean-mass were not associated with MFO. Long jump, relativized by lean-mass and by leg lean-mass have a standardized indirect effect on MFO of 0.50, CI: 0.32-0.70, on MFO/lean-mass 0.43, CI:0.27-0.60 and MFO/leg lean-mass 0.44, CI: 0.30-0.06, which VO
conclusionsMuscular strength and quality have an indirect effect on MFO mediated by VO
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